Nuclear protein of the testis midline carcinoma masquerading as a primary mediastinal seminoma

Abstract

Nuclear protein of the testis (NUT) midline carcinomas are rare aggressive carcinomas characterized by chromosomal rearrangements that involve the gene encoding the NUT. This article reviews the clinicopathologic features and the differential diagnosis of these malignancies.

Keywords

• Nuclear protein of the testis midline carcinoma
• primary mediastinal seminoma
• histone deacetylase inhibitors