NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety

Xiao Zhang; Yao Liu; Xiaoqi Hong; Xia Li; Charles K. Meshul; Cynthia Moore; Yabing Yang; Yanfei Han; Wei-Guang Li; Xin Qi; Huifang Lou; Shumin Duan; Tian-Le Xu; Xiaoping Tong

doi:10.1038/s41467-021-25956-y

Nature Communications (Sep 2021)

NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety

Xiao Zhang,
Yao Liu,
Xiaoqi Hong,
Xia Li,
Charles K. Meshul,
Cynthia Moore,
Yabing Yang,
Yanfei Han,
Wei-Guang Li,
Xin Qi,
Huifang Lou,
Shumin Duan,
Tian-Le Xu,
Xiaoping Tong

Affiliations

Xiao Zhang: Center for Brain Science, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
Yao Liu: Center for Brain Science, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
Xiaoqi Hong: Center for Brain Science, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
Xia Li: Institute of Special Environmental Medicine, Co-innovation Center of Neuroregeneration, Nantong University
Charles K. Meshul: Research Services, VA Medical Center
Cynthia Moore: Research Services, VA Medical Center
Yabing Yang: Center for Brain Science, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
Yanfei Han: Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine
Wei-Guang Li: Center for Brain Science, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
Xin Qi: Center for Brain Science, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
Huifang Lou: Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang University School of Medicine
Shumin Duan: Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang University School of Medicine
Tian-Le Xu: Center for Brain Science, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University
Xiaoping Tong: Center for Brain Science, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University

DOI: https://doi.org/10.1038/s41467-021-25956-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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Nerve/glial antigen 2 (NG2) glia can sense synaptic inputs from neurons. Here, the authors show NG2 glia form functional GABAergic synapses by regulating inhibitory synaptic transmission onto adjacent hippocampal interneurons, and activation of NG2 glia induces anxiety-like behaviour in a mouse model of chronic social defeat stress.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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