Association of serum stromal cell-derived factor 1 levels with EZSCAN score and its derived indicators in patients with type 2 diabetes

Abstract

Background: The aim of the study was to explore whether plasma stromal cel l-derived factor 1 (SDF-1) levels are associated with the EZSCAN score an d its derived indicators in patients with type 2 diabetes (T2D). Methods: From July 2020 to December 2020, a total of 253 patients with T2D were consecutively recruited. Serum SDF-1 levels were measured by sa ndwich ELISA. EZSCAN test was applied to evaluate the sudomotor function of each pat ient, and based on the results, EZSCAN score, cardiac autonomic neuropathy risk sc ore (CANRS) and cardiovascular risk score (CVDRS) were calculated by particular algorithms. In addition, other relevant clinical data were also collected. Results: With increasing tertiles of serum SDF-1 levels, the CANRS and CVDRS significantly increased (both P for trend <0.001), while the EZSCAN score significantly decrease d (P for trend <0.001). Moreover, serum SDF-1 levels were significant ly and positively correlated with the CANRS and CVDRS (r = 0.496 and 0.510, respectively, both P < 0.001), and negatively correlated with the EZSCAN score (r = −0.391, P < 0.001). Furthermore, multivariate linear regression analyses were constructed, and a fter adjusting for other clinical covariates, serum SDF-1 levels were independently resp onsible for EZSCAN score (β = −0.273, t = −3.679, P < 0.001), CANRS (β = 0.334, t = 5.110, P < 0.001) and CVDRS (β = 0.191, t = 4.983, P = 0.003). Conclusions: SDF-1 levels in serum were independently associated with the E ZSCAN score and its derived indicators, such as CANRS and CVDRS in patients with T2D.

Keywords

• type 2 diabetes
• stromal cell-derived factor 1
• ezscan
• cardiac autonomic neuropathy
• cardiovascular disease