Role of periosteum in alveolar bone regeneration comparing with collagen membrane in a buccal dehiscence model of dogs

Zhigui Ma; Ke Guo; Lu Chen; Xinwei Chen; Duohong Zou; Chi Yang

doi:10.1038/s41598-023-28779-7

Scientific Reports (Feb 2023)

Role of periosteum in alveolar bone regeneration comparing with collagen membrane in a buccal dehiscence model of dogs

Zhigui Ma,
Ke Guo,
Lu Chen,
Xinwei Chen,
Duohong Zou,
Chi Yang

Affiliations

Zhigui Ma: Department of Oral Surgery, College of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Ke Guo: Department of Stomatology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine
Lu Chen: Department of Oral Surgery, College of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Xinwei Chen: Department of Oral Surgery, College of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Duohong Zou: Department of Oral Surgery, College of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Chi Yang: Department of Oral Surgery, College of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

DOI: https://doi.org/10.1038/s41598-023-28779-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

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Abstract To investigate the role of periosteum on the treatment of buccal dehiscence defects comparing with collagen membrane in canine model. Bilateral dehiscence-type defects at the buccal side on the distal root of the lower 3rd/4th premolars were created in six beagle dogs with a total of 24 defects and assigned into three groups: Group A: blood clot in an untreated defect; Group B: deproteinized bovine bone material (DBBM) covered with an absorbable membrane; Group C: DBBM covered with the periosteum. The structural parameters for trabecular architecture and vertical bone regeneration were evaluated. Histological and histomorphometric evaluation were carried out to observe new bone formation and mineralization in the graft site. Immunohistochemical analysis was performed to identify the expression of osteopontin (OPN) and osteocalcin (OCN) at postoperative 3 months. Group C achieved greater vertical alveolar bone gain than that of group A and group B. The periosteum-covered group showed significantly greater new bone formation and accelerated mineralization. The greater immunolabeling for OPN and OCN was observed in group C than in group A. Periosteal coverage has explicit advantages over collagen membranes for the quality and quantity of new bone regeneration in dehiscence defects repairing.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

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