Nature Communications (Mar 2016)

Cadherin-11 localizes to focal adhesions and promotes cell–substrate adhesion

  • Rahul P. Langhe,
  • Tetyana Gudzenko,
  • Michael Bachmann,
  • Sarah F. Becker,
  • Carina Gonnermann,
  • Claudia Winter,
  • Genevieve Abbruzzese,
  • Dominique Alfandari,
  • Marie-Claire Kratzer,
  • Clemens M. Franz,
  • Jubin Kashef

DOI
https://doi.org/10.1038/ncomms10909
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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Cadherins are typically involved in cell-cell adhesion, however cadherin-11 promotes cell migration through an undefined mechanism. Langhe et al.show that cadherin-11 mediates adhesion to the cell matrix at focal adhesions through interaction with syndecan-4.