Results of propafenone use in early postoperative period after pulmonary veins catheter radiofrequency isolation for prevention of early atrial tachyarrhythmias

Abstract

Currently pulmonary veins isolation becomes one of the approaches for invasive treatment of paroxysmal atrial fibrillation (AF). One of difficult and unexplored problems associated with this procedure is management of patients in postoperative period (especially early) which is often complicated by frequent early recurrence of atrial tachyarrhythmias. The purpose of this study was to assess effectiveness and safety of IC antiarrhythmic drug propafenone for prevention of arrhythmia recurrence in the early postoperative period compared with placebo. Taking into account the inclusion and exclusion criteria 120 patients with paroxysmal AF were included and randomized and underwent radiofrequency ablation of pulmonary veins; 112 patients successfully finished the study. More than 57% of patients had early postoperative atrial tachyarrhythmias (AT) most of which were new and regular. Reduction of incidence of post-ablation AT during blanking period in propafenone group was clinically significant what was confirmed by patient’s diary and ECG-monitoring. Propafenone treatment within this period reduce the need for hospitalization or cardioversion without putting patient at risk of serious side effects associated with its prolonged use.

Keywords

• atrial fibrillation
• radiofrequency ablation of pulmonary veins
• early postoperative arrhythmias
• antiarrhythmic thera-py
• propafenone