Frontiers in Genetics (Feb 2024)
Connecting epigenetics and inflammation in vascular senescence: state of the art, biomarkers and senotherapeutics
- Oscar Fraile-Martinez,
- Oscar Fraile-Martinez,
- Diego De Leon-Oliva,
- Diego De Leon-Oliva,
- Diego Liviu Boaru,
- Diego Liviu Boaru,
- Patricia De Castro-Martinez,
- Patricia De Castro-Martinez,
- Cielo Garcia-Montero,
- Cielo Garcia-Montero,
- Silvestra Barrena-Blázquez,
- Silvestra Barrena-Blázquez,
- Joaquin García-García,
- Natalio García-Honduvilla,
- Natalio García-Honduvilla,
- Melchor Alvarez-Mon,
- Melchor Alvarez-Mon,
- Melchor Alvarez-Mon,
- Melchor Alvarez-Mon,
- Laura Lopez-Gonzalez,
- Laura Lopez-Gonzalez,
- Raul Diaz-Pedrero,
- Raul Diaz-Pedrero,
- Raul Diaz-Pedrero,
- Luis G. Guijarro,
- Luis G. Guijarro,
- Luis G. Guijarro,
- Luis G. Guijarro,
- Miguel A. Ortega,
- Miguel A. Ortega,
- Miguel A. Ortega,
- Miguel A. Ortega
Affiliations
- Oscar Fraile-Martinez
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala deHenares, Spain
- Oscar Fraile-Martinez
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Diego De Leon-Oliva
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala deHenares, Spain
- Diego De Leon-Oliva
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Diego Liviu Boaru
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala deHenares, Spain
- Diego Liviu Boaru
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Patricia De Castro-Martinez
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala deHenares, Spain
- Patricia De Castro-Martinez
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Cielo Garcia-Montero
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala deHenares, Spain
- Cielo Garcia-Montero
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Silvestra Barrena-Blázquez
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala deHenares, Spain
- Silvestra Barrena-Blázquez
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Joaquin García-García
- Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala deHenares, Spain
- Natalio García-Honduvilla
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala deHenares, Spain
- Natalio García-Honduvilla
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Melchor Alvarez-Mon
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala deHenares, Spain
- Melchor Alvarez-Mon
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Melchor Alvarez-Mon
- Network Biomedical Research Center for Liver and Digestive Diseases (CIBEREHD), Madrid, Spain
- Melchor Alvarez-Mon
- Immune System Diseases-Rheumatology, Oncology Service an Internal Medicine (CIBEREHD), University Hospital Príncipe de Asturias, Alcala deHenares, Spain
- Laura Lopez-Gonzalez
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Laura Lopez-Gonzalez
- Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala deHenares, Spain
- Raul Diaz-Pedrero
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Raul Diaz-Pedrero
- Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala deHenares, Spain
- Raul Diaz-Pedrero
- Department of General and Digestive Surgery, General and Digestive Surgery, Príncipe de Asturias Universitary Hospital, Alcala deHenares, Spain
- Luis G. Guijarro
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Luis G. Guijarro
- Network Biomedical Research Center for Liver and Digestive Diseases (CIBEREHD), Madrid, Spain
- Luis G. Guijarro
- Department of General and Digestive Surgery, General and Digestive Surgery, Príncipe de Asturias Universitary Hospital, Alcala deHenares, Spain
- Luis G. Guijarro
- Unit of Biochemistry and Molecular Biology, Department of System Biology (CIBEREHD), University of Alcalá, Alcala deHenares, Spain
- Miguel A. Ortega
- Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcala deHenares, Spain
- Miguel A. Ortega
- Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain
- Miguel A. Ortega
- Network Biomedical Research Center for Liver and Digestive Diseases (CIBEREHD), Madrid, Spain
- Miguel A. Ortega
- Cancer Registry and Pathology Department, Principe de Asturias University Hospital, Alcala deHenares, Spain
- DOI
- https://doi.org/10.3389/fgene.2024.1345459
- Journal volume & issue
-
Vol. 15
Abstract
Vascular diseases pose major health challenges, and understanding their underlying molecular mechanisms is essential to advance therapeutic interventions. Cellular senescence, a hallmark of aging, is a cellular state characterized by cell-cycle arrest, a senescence-associated secretory phenotype macromolecular damage, and metabolic dysregulation. Vascular senescence has been demonstrated to play a key role in different vascular diseases, such as atherosclerosis, peripheral arterial disease, hypertension, stroke, diabetes, chronic venous disease, and venous ulcers. Even though cellular senescence was first described in 1961, significant gaps persist in comprehending the epigenetic mechanisms driving vascular senescence and its subsequent inflammatory response. Through a comprehensive analysis, we aim to elucidate these knowledge gaps by exploring the network of epigenetic alterations that contribute to vascular senescence. In addition, we describe the consequent inflammatory cascades triggered by these epigenetic modifications. Finally, we explore translational applications involving biomarkers of vascular senescence and the emerging field of senotherapy targeting this biological process.
Keywords
- cellular senescence
- epigenetic modifications
- immune activation
- endothelial cells (ECs)
- vascular smooth muscle cells (VSMCs)
