Long-Term Cardiovascular Outcome in Children with MIS-C Linked to SARS-CoV-2 Infection—An Italian Multicenter Experience
Nicoletta Cantarutti,
Virginia Battista,
Nicola Stagnaro,
Marianna Eleonora Labate,
Marianna Cicenia,
Marta Campisi,
Valerio Vitali,
Aurelio Secinaro,
Andrea Campana,
Gianluca Trocchio,
Fabrizio Drago
Affiliations
Nicoletta Cantarutti
Cardiology and Arrhythmias Complex Unit, Department of Paediatric Cardiology and Cardiac Surgery, Bambino Gesù Children’s Hospital, IRCCS, 00163 Rome, Italy
Virginia Battista
Cardiology and Arrhythmias Complex Unit, Department of Paediatric Cardiology and Cardiac Surgery, Bambino Gesù Children’s Hospital, IRCCS, 00163 Rome, Italy
Nicola Stagnaro
Radiology Unit, IRCCS Istituto Giannina Gaslini, 16132 Genoa, Italy
Marianna Eleonora Labate
Department of Internal Medicine and Medical Specialities (DIMI), Clinic of Cardiovascular Diseases, University of Genoa, 16132 Genoa, Italy
Marianna Cicenia
Cardiology and Arrhythmias Complex Unit, Department of Paediatric Cardiology and Cardiac Surgery, Bambino Gesù Children’s Hospital, IRCCS, 00163 Rome, Italy
Marta Campisi
Cardiology and Arrhythmias Complex Unit, Department of Paediatric Cardiology and Cardiac Surgery, Bambino Gesù Children’s Hospital, IRCCS, 00163 Rome, Italy
Valerio Vitali
Cardiology and Arrhythmias Complex Unit, Department of Paediatric Cardiology and Cardiac Surgery, Bambino Gesù Children’s Hospital, IRCCS, 00163 Rome, Italy
Aurelio Secinaro
Advanced Cardiothoracic Imaging Unit, Department of Imaging, Bambino Gesù Children’s Hospital IRCSS, 00163 Rome, Italy
Andrea Campana
Academic Department of Pediatrics, Bambino Gesù Children’s Hospital, IRCCS, 00163 Rome, Italy
Gianluca Trocchio
Cardiology Unit, IRCCS Istituto Giannina Gaslini, 16132 Genoa, Italy
Fabrizio Drago
Cardiology and Arrhythmias Complex Unit, Department of Paediatric Cardiology and Cardiac Surgery, Bambino Gesù Children’s Hospital, IRCCS, 00163 Rome, Italy
MIS-C is a multisystem inflammatory syndrome that is characterized by multi-organ failure and cardiac involvement. The aim of this study was to describe the long-term cardiovascular outcome in a cohort of MIS-C pediatric patients, who were admitted to two Italian Pediatric Referral Centers. Sixty-seven patients (mean age 8.7 ± 4.7 years, male 60%) were included; 65 (97%) of them showed cardiac involvement. All of the patients completed one month of the follow-up, and 47% completed 1 year of it. ECG abnormalities were present in 65% of them, arrhythmias were present in 9% of them during an acute phase and it disappeared at the point of discharge or later. Pericarditis were detected in 66% of them and disappeared after 6 months. Coronaritis was observed in 35% of the children during an acute phase, and there were no more instances at the 1-year point. An LV dysfunction was present in 65% of the patients at the beginning of the study, with them having a full recovery at the point of discharge and thereafter. Elevated values of the NTproBNP and hsTp were initially detected, which progressively decreased and normalized at the points of discharge and FU. The CMR at the point of FU, there was a presence of long-term myocardial scars in 50% of the patients that were tested. No deaths that were caused by MIS-C during the FU were recorded. Cardiac involvement in MIS-C patients is almost the rule, but the patients’ clinical course was satisfactory, and no additional events or sequelae were observed apart from there being long-term myocardial scars in 50% of the patients that underwent CMR.
