Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts

Hu Xianwen; Hu Hongyu; Li Dandan; Wang Pan; Cai Jiong

doi:10.1515/med-2024-1027

Open Medicine (Sep 2024)

Affibody-based molecular probe 99mTc-(HE)3ZHER2:V2 for non-invasive HER2 detection in ovarian and breast cancer xenografts

Hu Xianwen,
Hu Hongyu,
Li Dandan,
Wang Pan,
Cai Jiong

Affiliations

Hu Xianwen: Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Huichuan, Zunyi, 563003, China
Hu Hongyu: Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Huichuan, Zunyi, 563003, China
Li Dandan: Department of Obstetrics, Zunyi Hospital of Traditional Chinese Medicine, Zunyi, Guizhou, Zunyi, 563003, China
Wang Pan: Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Huichuan, Zunyi, 563003, China
Cai Jiong: Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Huichuan, Zunyi, 563003, China

DOI: https://doi.org/10.1515/med-2024-1027
Journal volume & issue: Vol. 19, no. 1
pp. 5361 – 6

Abstract

Read online

This study aimed to assess the biodistribution and bioactivity of the affibody molecular probe 99mTc-(HE)3ZHER2:V2, prepared by genetic recombination, and to investigate its potential for targeted human epidermal growth factor receptor 2 (HER2) imaging in SKOV3 ovarian cancer and MDA-MB-361 breast cancer xenografts.

Published in Open Medicine

ISSN: 2391-5463 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine
Website: https://www.degruyter.com/journal/key/med/html

About the journal

Abstract

Keywords