CHANGES IN SENSITIVITY TO SKIN TEST WITH RECOMBINANT TUBERCULOUS ALLERGEN IN CHILDREN WITH LATENT TUBERCULOSIS INFECTION

Abstract

The sensitivity to tuberculin and recombinant tuberculous allergen was assessed in 433 children with latent tuberculous infection from various epidemic conditions [exposure to a TB case (n = 202), from healthy surrounding (n = 231); changes in the results of diaskintest were assessed in 209 children (when notified and in 12 months). It was found out that expressiveness and changes in the sensitivity to tuberculous recombinant allergen depends on the epidemic conditions to which the child is exposed. The most often the conversion of the diaskintest was observed after preventive treatment in those with doubtful (95.5%) and hyperergic (82.6%) sensitivity. Conversion of the test from negative to positive was most often observed in children from healthy surroundings.

Keywords

• латентная туберкулезная инфекция
• чувствительность к аллергену туберкулезному рекомбинантному
• проба с диаскинтестом
• чувствительность к туберкулину