Incidence rate, basic characteristics, and survival outcomes of bladder squamous cell carcinoma

Abstract

Abstract To explore the incidence rate (IR), clinicopathological characteristics, and prognostic factors of bladder squamous cell carcinoma (BSCC) based on surveillance, epidemiology, and end results (SEER) database. We extracted the IRs of BSCC from 1975 to 2016 in the SEER database, and plotted the trending curves. Then, the clinicopathological characteristics of BSCC patients diagnosed from 2010 to 2015 were selected and compared with those of patients with urothelial carcinoma (UC) in the same period. Furthermore, differences in overall survival (OS) and cancer‐specific survival (CSS) of BSCC and UC patients were compared. Finally, COX regression models were constructed to explore the risk factors affecting OS and CSS in BSCC patients. The IR of BSCC showed a downward trend from 1975 to 2000 and stabilized at about 0.3/100 000 after 2000. BSCC patients had a later stage at diagnosis and worse prognosis when compared with those with UC. Older age, higher TNM stage, no surgical treatment, and unmarried status were significantly related to worse prognosis of BSCC patients. This study explored the IR trends, clinicopathological characteristics, and prognostic factors of BSCC. In the future, prospective, large sample, and well‐designed clinical studies are needed to verify our results.

Keywords

• bladder squamous cell carcinoma
• clinical characteristics
• incidence rate
• prognosis
• SEER