A Case Report of Polyostotic form of Fibrous Dysplasia: Imaging Features in Radiograph, Computed Tomography and Magnetic Resonance Imaging

Abstract

Fibrous dysplasia is a disease that causes aberrant development of osteoblasts, which results in fibrous stroma replacing normal bone. Lichtenstein first described it in 1938. It is a sporadic disorder caused due to a postzygotic mutation in the GNAS1 gene. It can affect a single bone (monostotic) or several bones (polyostotic). The most common locations are the skull & ribs. It is typically an incidental finding and asymptomatic. When a pathologic fracture or malignant alteration complicates it, symptoms could develop. As polyostotic FD is a rare disorder that only occasionally occurs in 20–25% of patients, therefore the aim of this article is to report such a rare case of polyostotic FD in a 30-year-old female patient showing the characteristic changes. Keywords: Polyostotic fibrous dysplasia, GNAS1 gene mutation, Sporadic disorder