A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis

Ines Jeric; Gabriele Maurer; Anna Lina Cavallo; Josipa Raguz; Enrico Desideri; Bartosz Tarkowski; Matthias Parrini; Irmgard Fischer; Kurt Zatloukal; Manuela Baccarini

doi:10.1038/ncomms13781

Nature Communications (Dec 2016)

A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis

Ines Jeric,
Gabriele Maurer,
Anna Lina Cavallo,
Josipa Raguz,
Enrico Desideri,
Bartosz Tarkowski,
Matthias Parrini,
Irmgard Fischer,
Kurt Zatloukal,
Manuela Baccarini

Affiliations

Ines Jeric: Department of Microbiology, Immune biology, and Genetics, Center for Molecular Biology, University of Vienna—Max F. Perutz Laboratories
Gabriele Maurer: Department of Microbiology, Immune biology, and Genetics, Center for Molecular Biology, University of Vienna—Max F. Perutz Laboratories
Anna Lina Cavallo: Department of Microbiology, Immune biology, and Genetics, Center for Molecular Biology, University of Vienna—Max F. Perutz Laboratories
Josipa Raguz: Department of Microbiology, Immune biology, and Genetics, Center for Molecular Biology, University of Vienna—Max F. Perutz Laboratories
Enrico Desideri: Department of Microbiology, Immune biology, and Genetics, Center for Molecular Biology, University of Vienna—Max F. Perutz Laboratories
Bartosz Tarkowski: Department of Microbiology, Immune biology, and Genetics, Center for Molecular Biology, University of Vienna—Max F. Perutz Laboratories
Matthias Parrini: Department of Microbiology, Immune biology, and Genetics, Center for Molecular Biology, University of Vienna—Max F. Perutz Laboratories
Irmgard Fischer: Department of Microbiology, Immune biology, and Genetics, Center for Molecular Biology, University of Vienna—Max F. Perutz Laboratories
Kurt Zatloukal: Institute of Pathology, Medical University of Graz
Manuela Baccarini: Department of Microbiology, Immune biology, and Genetics, Center for Molecular Biology, University of Vienna—Max F. Perutz Laboratories

DOI: https://doi.org/10.1038/ncomms13781
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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The kinase RAF1 usually exerts pro-tumorigenic functions promoting proliferation in RAS-driven cancers. Here, the authors using a mouse model of HCC and clinical data describe an unexpected oncosuppressor role of RAF1 in hepatocarcinoma development linked to a gp130-dependent Stat3 activation and YAP1 regulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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