Фармакокинетика и Фармакодинамика (Jan 2024)

Placenta peptides: antibacterial effects

  • I. Yu. Torshin,
  • T. E. Bogacheva,
  • O. A. Gromova

DOI
https://doi.org/10.37489/2587-7836-2023-4-15-22
Journal volume & issue
Vol. 0, no. 4
pp. 15 – 22

Abstract

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Mass spectrometric sequencing of peptides in Laennec indicated the presence of 5 peptides in the drug, the biological activity of which may determine the antibacterial properties of the drug. The most significant result of this study is the presence in Laennec of a fragment of the antibacterial peptide cathelicidin (LL-37), an important vitamin D-dependent factor of innate immunity. Other Laennec peptides help reduce excess inflammation by inhibiting the activity of the NF-kB protein, which mediates the effects of TNF-α.

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