Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma

Alexander A. Strait; Rachel A. Woolaver; Spencer C. Hall; Christian D. Young; Sana D. Karam; Antonio Jimeno; Yan Lan; David Raben; Jing H. Wang; Xiao-Jing Wang

doi:10.1038/s42003-021-02522-2

Communications Biology (Aug 2021)

Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma

Alexander A. Strait,
Rachel A. Woolaver,
Spencer C. Hall,
Christian D. Young,
Sana D. Karam,
Antonio Jimeno,
Yan Lan,
David Raben,
Jing H. Wang,
Xiao-Jing Wang

Affiliations

Alexander A. Strait: Department of Pathology, University of Colorado, Anschutz Medical Campus
Rachel A. Woolaver: Department of Immunology and Microbiology, University of Colorado, Anschutz Medical Campus
Spencer C. Hall: Department of Pathology, University of Colorado, Anschutz Medical Campus
Christian D. Young: Department of Pathology, University of Colorado, Anschutz Medical Campus
Sana D. Karam: Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus
Antonio Jimeno: Department of Medicine, University of Colorado, Anschutz Medical Campus
Yan Lan: EMD Serono Research and Development Institute Inc.
David Raben: Department of Radiation Oncology, University of Colorado, Anschutz Medical Campus
Jing H. Wang: Department of Immunology and Microbiology, University of Colorado, Anschutz Medical Campus
Xiao-Jing Wang: Department of Pathology, University of Colorado, Anschutz Medical Campus

DOI: https://doi.org/10.1038/s42003-021-02522-2
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 15

Abstract

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Strait et al describe distinct immune microenvironment profiles of responders versus non-responders to combined TGF-β/PD-L1 blockade in mouse models of squamous cell carcinoma (SCC). The results emphasize the potential of combined TGF-β/PD-L1 targeting and provide important clues to guide personalized SCC immunotherapy.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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