Pathway dependent controlled supramolecular polymerization of peptides

Abstract

Recently, pathway complexity in supramolecular self-assembly has gained great attention due to their ability to control over the dimensions of the nanostructures. Although, the self-assembly of a wide range of organic and π-chromophore-based compounds have been extensively explored in the context of pathway complexity, analogous investigations using peptides have so far received less attention. In this Minireview, we have collated recent examples on control over nano- and secondary structures of self-assembled peptides through pathway dependent approaches. Regulating the competing kinetic vs thermodynamic pathways would aid to create tunable nanostructures with definite size and shape which is very crucial for effective interactions with biological systems and wide variety of applications in biomedicine.

Keywords

• Supramolecular self-assembly
• Peptides
• Pathway complexity
• Nanostructures
• Secondary structures