Communications Biology (May 2021)

Structural analogues in herbal medicine ginseng hit a shared target to achieve cumulative bioactivity

  • Wei Zhang,
  • Wei-Wei Tao,
  • Jing Zhou,
  • Cheng-Ying Wu,
  • Fang Long,
  • Hong Shen,
  • He Zhu,
  • Qian Mao,
  • Jun Xu,
  • Song-Lin Li,
  • Qi-Nan Wu

DOI
https://doi.org/10.1038/s42003-021-02084-3
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 14

Abstract

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Zhang et al. design ginsenoside structural analogues and demonstrate that their combination shows more potent immunomodulatory activities than individual ginsenosides used alone at the same dosages. They predict that these analogues act on the joint target NLRP3 and consequently suggest that structural analogues hit a shared target to achieve cumulative bioactivity.