Retrovirus infected cells contain viral microRNAs

Abstract

Abstract The encoding of microRNAs in retroviral genomes has remained a controversial hypothesis despite significant supporting evidence in recent years. A recent publication demonstrating the production of functional miRNAs from the retrovirus bovine leukemia virus adds further credence to the fact that retroviruses do indeed encode their own miRNAs. Here we comment on the importance of this paper to the field, as well as examine the other known examples of miRNAs encoded by RNA viruses.

Keywords

• Retrovirus
• microRNA
• Bovine leukemia virus
• Human immunodeficiency virus
• West nile virus
• Transcriptional gene silencing
• RNA polymerase III