Diabetes, Metabolic Syndrome and Obesity (Jul 2022)
Research Progress on Relationship Between Iron Overload and Lower Limb Arterial Disease in Type 2 Diabetes Mellitus
Abstract
Zhongjing Wang,1,* Shu Fang,1,2,* Sheng Ding,1 Qin Tan,1 Xuyan Zhang1 1Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, People’s Republic of China; 2School of Medicine, Jianghan University, Wuhan, 430056, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuyan Zhang, Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 of Shengli Street, Jiang’an District, Wuhan, 430014, People’s Republic of China, Tel +86 027 6569 6337, Fax +86 027 8276 1417, Email [email protected]: Iron is one of the most important trace elements in life activities. It participates in a variety of important physiological processes in the body through oxidation-reduction reaction. A large number of studies show that iron overload (IO) is closely related to the progression of diabetes and its various chronic complications. However, the mechanism of iron overload in the pathogenesis of diabetes and the mechanism of iron overload in atherosclerosis (AS) are still controversial, and the relationship between iron overload and diabetic lower extremity arterial disease (LEAD) remains still unclear. Some recent reviews and original research articles suggest further studies to explain the complex relationship between iron metabolism and atherosclerosis. This article reviews the relationship between iron overload and diabetes and its relationship with LEAD, and discusses its mechanisms from various aspects, such as lipid peroxidation induced by iron overload, so as to provide clinical diagnosis and treatment ideas for diabetic lower extremity arterial disease. It is hoped that early evaluation, diagnosis and treatment of LEAD will be inspired.Keywords: iron overload, lower extremity arterial disease, atherosclerosis, serum ferritin, type 2 diabetes mellitus
