Nature Communications (Sep 2021)
Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence
- Q. Heydt,
- C. Xintaropoulou,
- A. Clear,
- M. Austin,
- I. Pislariu,
- F. Miraki-Moud,
- P. Cutillas,
- K. Korfi,
- M. Calaminici,
- W. Cawthorn,
- K. Suchacki,
- A. Nagano,
- J. G. Gribben,
- M. Smith,
- J. D. Cavenagh,
- H. Oakervee,
- A. Castleton,
- D. Taussig,
- B. Peck,
- A. Wilczynska,
- L. McNaughton,
- D. Bonnet,
- F. Mardakheh,
- B. Patel
Affiliations
- Q. Heydt
- Centre for Haemato-Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London
- C. Xintaropoulou
- Centre for Haemato-Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London
- A. Clear
- Centre for Haemato-Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London
- M. Austin
- Centre for Haemato-Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London
- I. Pislariu
- Centre for Haemato-Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London
- F. Miraki-Moud
- Centre for Haemato-Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London
- P. Cutillas
- Centre for Haemato-Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London
- K. Korfi
- Centre for Haemato-Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London
- M. Calaminici
- Centre for Haemato-Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London
- W. Cawthorn
- BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh
- K. Suchacki
- BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh
- A. Nagano
- Centre for Molecular Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London
- J. G. Gribben
- Centre for Haemato-Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London
- M. Smith
- Department of Haemato-Oncology, St Bartholomew’s Hospital, West Smithfield
- J. D. Cavenagh
- Department of Haemato-Oncology, St Bartholomew’s Hospital, West Smithfield
- H. Oakervee
- Department of Haemato-Oncology, St Bartholomew’s Hospital, West Smithfield
- A. Castleton
- Christie NHS Foundation Trust
- D. Taussig
- Haemato-oncology Unit, The Royal Marsden Hospital
- B. Peck
- Centre for Tumour Biology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London
- A. Wilczynska
- CRUK Beatson Institute
- L. McNaughton
- Haematopoietic Stem Cell Laboratory, The Francis Crick Institute
- D. Bonnet
- Haematopoietic Stem Cell Laboratory, The Francis Crick Institute
- F. Mardakheh
- Centre for Molecular Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London
- B. Patel
- Centre for Haemato-Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London
- DOI
- https://doi.org/10.1038/s41467-021-25540-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
How the bone marrow microenvironment evolves during induction chemotherapy to facilitate acute lymphoblastic leukaemia (ALL) survival remains unclear. Here the authors show that adipocytes emergent during ALL therapy aid the survival of ALL cells through a restrictive effect on the ALL proteome.
