Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch

Abstract

Gastrin-releasing peptide receptors (GRPR) are involved in pruriceptive behaviours. Here the authors show that neuronal pentraxin 2 upregulated in primary sensory neurons in chronic itch models is required for facilitating excitatory synaptic inputs onto GRPR expressing spinal neurons.