WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis

Vasilios Tsarouhas; Dan Liu; Georgia Tsikala; Alina Fedoseienko; Kai Zinn; Ryo Matsuda; Daniel D. Billadeau; Christos Samakovlis

doi:10.1038/s41467-019-10229-6

Nature Communications (May 2019)

WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis

Vasilios Tsarouhas,
Dan Liu,
Georgia Tsikala,
Alina Fedoseienko,
Kai Zinn,
Ryo Matsuda,
Daniel D. Billadeau,
Christos Samakovlis

Affiliations

Vasilios Tsarouhas: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Dan Liu: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Georgia Tsikala: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Alina Fedoseienko: Department of Biochemistry and Division of Oncology Research, College of Medicine, Mayo Clinic
Kai Zinn: Division of Biology and Biological Engineering, California Institute of Technology
Ryo Matsuda: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Daniel D. Billadeau: Department of Biochemistry and Division of Oncology Research, College of Medicine, Mayo Clinic
Christos Samakovlis: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University

DOI: https://doi.org/10.1038/s41467-019-10229-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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The regulation and coordination of F-actin networks are not well understood. Here, the authors show an antagonistic relationship between endosomal F-actin assembly and cortical bundle integrity during epithelial tube maturation that is regulated by kinase and phosphatase activity modifying WASH.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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