Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2

Young Rae Ji; Yosuke Tona; Talah Wafa; Matthew E. Christman; Edward D. Tourney; Tao Jiang; Sho Ohta; Hui Cheng; Tracy Fitzgerald; Bernd Fritzsch; Sherri M. Jones; Kathleen E. Cullen; Doris K. Wu

doi:10.1038/s41467-022-33819-3

Nature Communications (Oct 2022)

Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2

Young Rae Ji,
Yosuke Tona,
Talah Wafa,
Matthew E. Christman,
Edward D. Tourney,
Tao Jiang,
Sho Ohta,
Hui Cheng,
Tracy Fitzgerald,
Bernd Fritzsch,
Sherri M. Jones,
Kathleen E. Cullen,
Doris K. Wu

Affiliations

Young Rae Ji: Section on Sensory Cell Regeneration and Development, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
Yosuke Tona: Section on Sensory Cell Regeneration and Development, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
Talah Wafa: Mouse Auditory Testing Core Facility, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
Matthew E. Christman: Department of Biomedical Engineering, Johns Hopkins University School of Medicine
Edward D. Tourney: Department of Biomedical Engineering, Johns Hopkins University School of Medicine
Tao Jiang: Section on Sensory Cell Regeneration and Development, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
Sho Ohta: Section on Sensory Cell Regeneration and Development, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
Hui Cheng: Bioinformatics and Biostatistics Collaboration Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
Tracy Fitzgerald: Mouse Auditory Testing Core Facility, National Institute on Deafness and Other Communication Disorders, National Institutes of Health
Bernd Fritzsch: Department of Biology & Department of Otolaryngology, University of Iowa
Sherri M. Jones: Department of Special Education and Communication Disorders, 301 Barkley Memorial Center, University of Nebraska-Lincoln
Kathleen E. Cullen: Department of Biomedical Engineering, Johns Hopkins University School of Medicine
Doris K. Wu: Section on Sensory Cell Regeneration and Development, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health

DOI: https://doi.org/10.1038/s41467-022-33819-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

Read online

The inner ear is highly organized, with distinct domains being located across the Line of Polarity Reversal (LPR). Here they show that Emx2 establishes the LPR and bidirectional selectivity of otolith organs, and that loss of the LPR in mice affects swimming and balance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal