International Journal of Infectious Diseases (Mar 2020)
MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network
- Giovanni Battista Migliori,
- Simon Tiberi,
- Alimuddin Zumla,
- Eskild Petersen,
- Jeremiah Muhwa Chakaya,
- Christian Wejse,
- Marcela Muñoz Torrico,
- Raquel Duarte,
- Jan Willem Alffenaar,
- H. Simon Schaaf,
- Ben J. Marais,
- Daniela Maria Cirillo,
- Riccardo Alagna,
- Adrian Rendon,
- Emanuele Pontali,
- Alberto Piubello,
- José Figueroa,
- Gabriella Ferlazzo,
- Alberto García-Basteiro,
- Rosella Centis,
- Dina Visca,
- Lia D’Ambrosio,
- Giovanni Sotgiu,
- T. Abu Arkub,
- O.W. Akkerman,
- A. Aleksa,
- E. Belilovski,
- E. Bernal,
- F-X. Blanc,
- M. Boeree,
- S. Borisov,
- J. Bruchfeld,
- J. Cadiñanos Loidi,
- J.A. Caminero,
- A.C. Carvalho,
- J.J. Cebrian Gallardo,
- Charalampos,
- E. Danila,
- L. Davies Forsman,
- J. Denholm,
- K. Dheda,
- R. Diel,
- S. Diktanas,
- C. Dobler,
- M. Enwerem,
- S. Esposito,
- N. Escobar Salinas,
- A. Filippov,
- B. Formenti,
- J.M. García García,
- D. Goletti,
- R. Gomez Rosso,
- G. Gualano,
- P. Isaakidis,
- A. Kaluzhenina,
- S. Koirala,
- L. Kuksa,
- H. Kunst,
- Y. Li,
- C. Magis-Escurra,
- V. Manfrin,
- S. Manga,
- K. Manika,
- V. Marchese,
- E. Martínez Robles,
- A. Maryandyshev,
- A. Matteelli,
- A. Mariani,
- J. Mazza-Stalder,
- F. Mello,
- L. Mendoza,
- A. Mesi,
- S. Miliauskas,
- H. Mustafa Hamdan,
- N. Ndjeka,
- M. Nieto Marcos,
- T.H.M. Ottenhoff,
- D.J. Palmero,
- F. Palmieri,
- A. Papavasileiou,
- M.C. Payen,
- A. Pontarelli,
- M. Pretti Dalcolmo,
- S. Quirós Fernandez,
- R. Romero,
- D. Rossato Silva,
- A.P. Santos,
- B. Seaworth,
- M. Sinitsyn,
- A. Skrahina,
- I. Solovic,
- A. Spanevello,
- M. Tadolini,
- C. Torres,
- Z. Udwadia,
- M. van den Boom,
- G.V. Volchenkov,
- A. Yedilbayev,
- R. Zaleskis,
- J.P. Zellweger
Affiliations
- Giovanni Battista Migliori
- Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Via Roncaccio 16, Tradate, Varese, 21049, Italy; Corresponding author.
- Simon Tiberi
- Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; Division of Infection, Royal London Hospital, Barts Health NHS Trust, London, United Kingdom
- Alimuddin Zumla
- Division of Infection and Immunity, University College London and NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, United Kingdom
- Eskild Petersen
- Directorate General for Disease Surveillance and Control, Ministry of Health, Muscat, Oman; Institute for Clinical Medicine, Faculty of Health Science, University of Aarhus, Denmark; ESCMID Emerging Infections Task Force, Basel, Switzerland
- Jeremiah Muhwa Chakaya
- The International Union Against Tuberculosis and Lung Disease, Paris, France; Department of Medicine, Therapeutics, Dermatology and Psychiatry, Kenyatta University, Nairobi, Kenya
- Christian Wejse
- Department of Infectious Disease, Aarhus University Hospital and School of Public Health, Faculty of Health Sciences, University of Aarhus, Denmark
- Marcela Muñoz Torrico
- Clínica de Tuberculosis, Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, Mexico
- Raquel Duarte
- National Reference Centre for MDR-TB, Hospital Centre Vila Nova de Gaia, Department of Pneumology, Public Health Science and Medical Education Department, Faculty of Medicine, University of Porto, Porto, Portugal
- Jan Willem Alffenaar
- Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia; Westmead Hospital, Sydney, Australia; Dept. Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
- H. Simon Schaaf
- Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
- Ben J. Marais
- The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia; The University of Sydney Marie Bashir Institute for Infectious Diseases and Biosecurity, Sydney, New South Wales, Australia
- Daniela Maria Cirillo
- Emerging Pathogens Unit, TB Supranational Reference Laboratory, San Raffaele Scientific Institute, Milan, Italy
- Riccardo Alagna
- Emerging Pathogens Unit, TB Supranational Reference Laboratory, San Raffaele Scientific Institute, Milan, Italy
- Adrian Rendon
- Centro de Investigación, Prevención y Tratamiento de Infecciones Respiratorias CIPTIR, University Hospital of Monterrey UANL (Universidad Autonoma de Nuevo Leon), Monterrey, Mexico
- Emanuele Pontali
- Department of Infectious Diseases, Galliera Hospital, Genova, Italy
- Alberto Piubello
- The International Union Against Tuberculosis and Lung Disease, Paris, France; Tuberculosis Division, Damien Foundation, Niamey, Niger
- José Figueroa
- National Health Service (NHS) England, London, United Kingdom
- Gabriella Ferlazzo
- Southern Africa Medical Unit, Médecins Sans Frontières, Cape Town, South Africa
- Alberto García-Basteiro
- Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique; ISGlobal, Barcelona Centre for International Health Research, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain
- Rosella Centis
- Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Via Roncaccio 16, Tradate, Varese, 21049, Italy
- Dina Visca
- Division of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri, IRCCS, Tradate, Italy; Department of Medicine and Surgery, Respiratory Diseases, University of Insubria, Varese, Italy
- Lia D’Ambrosio
- Public Health Consulting Group, Lugano, Switzerland
- Giovanni Sotgiu
- Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy
- T. Abu Arkub
- Russian Federation
- O.W. Akkerman
- Netherlands
- A. Aleksa
- Belarus
- E. Belilovski
- Russian Federation
- E. Bernal
- Spain
- F-X. Blanc
- France
- M. Boeree
- Netherlands
- S. Borisov
- Russian Federation
- J. Bruchfeld
- Sweden
- J. Cadiñanos Loidi
- Spain
- J.A. Caminero
- Spain
- A.C. Carvalho
- Brazil
- J.J. Cebrian Gallardo
- Spain
- Charalampos
- Greece
- E. Danila
- Lithuania
- L. Davies Forsman
- Sweden
- J. Denholm
- Russian Federation; Netherlands; Belarus; Spain; France; Sweden; Brazil; Greece; Lithuania; Australia; South Africa; Germany; Italy; Chile; Paraguay; Nepal; Latvia; UK; China; Peru; Switzerland; Albania; Sudan; Argentina; Belgium; USA; Slovakia; Colombia; India; Denmark
- K. Dheda
- South Africa
- R. Diel
- Germany
- S. Diktanas
- Lithuania
- C. Dobler
- Australia
- M. Enwerem
- South Africa
- S. Esposito
- Italy
- N. Escobar Salinas
- Chile
- A. Filippov
- Russian Federation
- B. Formenti
- Italy
- J.M. García García
- Spain
- D. Goletti
- Italy
- R. Gomez Rosso
- Paraguay
- G. Gualano
- Italy
- P. Isaakidis
- South Africa
- A. Kaluzhenina
- Russian Federation
- S. Koirala
- Nepal
- L. Kuksa
- Latvia
- H. Kunst
- UK
- Y. Li
- China
- C. Magis-Escurra
- Netherlands
- V. Manfrin
- Italy
- S. Manga
- Peru
- K. Manika
- Greece
- V. Marchese
- Italy
- E. Martínez Robles
- Spain
- A. Maryandyshev
- Russian Federation
- A. Matteelli
- Italy
- A. Mariani
- Brazil
- J. Mazza-Stalder
- Switzerland
- F. Mello
- Brazil
- L. Mendoza
- Chile
- A. Mesi
- Albania
- S. Miliauskas
- Lithuania
- H. Mustafa Hamdan
- Sudan
- N. Ndjeka
- South Africa
- M. Nieto Marcos
- Spain
- T.H.M. Ottenhoff
- Netherlands
- D.J. Palmero
- Argentina
- F. Palmieri
- Italy
- A. Papavasileiou
- Greece
- M.C. Payen
- Belgium
- A. Pontarelli
- Italy
- M. Pretti Dalcolmo
- Brazil
- S. Quirós Fernandez
- Spain
- R. Romero
- South Africa
- D. Rossato Silva
- Brazil
- A.P. Santos
- Brazil
- B. Seaworth
- USA
- M. Sinitsyn
- Russian Federation
- A. Skrahina
- Belarus
- I. Solovic
- Slovakia
- A. Spanevello
- Italy
- M. Tadolini
- Italy
- C. Torres
- Colombia
- Z. Udwadia
- India
- M. van den Boom
- Denmark
- G.V. Volchenkov
- Russian Federation
- A. Yedilbayev
- Denmark
- R. Zaleskis
- Latvia
- J.P. Zellweger
- Switzerland
- Journal volume & issue
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Vol. 92
pp. S15 – S25
Abstract
The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts.The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines.After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities. Keywords: MDR-TB, XDR-TB, Diagnosis, Treatment, Prevention, Rehabilitation of sequelae
