Pathogenesis and correction of anemic syndrome in lymphoproliferative disorders patients

Abstract

The paper presents a lecture that considers the major pathogenetic mechanisms of development and the specific features of the course of anemia syndrome in patients with lymphoproliferative diseases (LPD). It gives a classification of chronic anemia and methods of its treatment. Emphasis is placed on the correction of anemia by packed red blood cell transfusion; indications for the latter, its efficiency, and posttransfusion complications are outlined. A case of successful pathogenetic treatment is demonstrated in a female patient with non-Hodgkin’s lymphoma concurrent with Evans’ syndrome. The lecture also details anemia therapy with erythropoiesis-stimulating drugs in patients with LPD and gives the characteristics of different medications, algorithms and indications for their use, efficacy evaluation, and possible side effects. Prognostic factors for the efficacy of epoietins are given in relation to a number of laboratory tests.

Keywords

• anemia
• lymphoma
• lymphoproliferative disorders
• multiple myeloma
• erythropoietin
• erythropoiesis-stimulating agents
• chemotherapy
• red blood cells transfusion
• evans syndrome
• epoetin-a
• pathogenesis anemia