Nature Communications (Feb 2018)

Enhancing Hi-C data resolution with deep convolutional neural network HiCPlus

  • Yan Zhang,
  • Lin An,
  • Jie Xu,
  • Bo Zhang,
  • W. Jim Zheng,
  • Ming Hu,
  • Jijun Tang,
  • Feng Yue

DOI
https://doi.org/10.1038/s41467-018-03113-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Despite its popularity for measuring the spatial organization of mammalian genomes, the resolution of most Hi-C datasets is coarse due to sequencing cost. Here, Zhang et al. develop HiCPlus, a computational approach based on deep convolutional neural network, to infer high-resolution Hi-C interaction matrices from low-resolution Hi-C data.