Case Reports in Dermatology (Jun 2013)

A Case of Foreign-Body Granuloma of the Glabella due to Polyacrylamide Filler and an Intractable Ulcer after Skin Biopsy: An Immunohistochemical Evaluation of Inflammatory Changes

  • Kio Park,
  • Fuyuko Nishiwaki,
  • Kenji Kabashima,
  • Yoshiki Miyachi

DOI
https://doi.org/10.1159/000353346
Journal volume & issue
Vol. 5, no. 2
pp. 181 – 185

Abstract

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Introduction: Polyacrylamide hydrogel has been considered a safe and biocompatible soft tissue filler, and it has been widely used in cosmetic procedures. However, recent studies have revealed some complications with polyacrylamide filler injections. Case Report: We present the case of foreign-body granulomas of the glabella, which subsequently formed an infectious ulcer 3 years after a polyacrylamide injection. An immunohistochemical evaluation of the foreign-body granulomas was performed in order to study the relationship between foreign-body granulomas and immune response. Conclusion: We believe that our analysis of foreign-body granulomas 1 and 3 years after a filler injection may contribute to revealing the mechanism of chronic and intractable infections after filler injections.

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