IMMUNE STATUS AND ITS CORRECTION IN CEREBRAL STROKE

Abstract

Abstract. The purpose of the present investigation was to study the immune status of the patients with acute stroke (54 patients with cerebral infarction; 34 — with cerebral hemorrhage). Evaluation of the immune status included the study of the population and subpopulation composition of the peripheral blood lymphocytes by means of an indirect immunofluorescent method using monoclonal antibodies CD3, CD4, CD8, CD16, CD20, CD25, CD71, CD95, the determination of IgM, IgG, IgA , circulating immune complexes levels, investigation of neutrophil phagocytic activity. It was shown that the patients with stroke have the obvious suppression of Т–cell mediated immunity and the decrease of the neutrophil phagocytic activity as well as hyperactivation of humoral immunity. 30 patients received immunity modulator twice: repeated subcutaneous injection of roncoleukin (500000 IU) at intervals of 72 hours. The administration of roncoleukin resulted in the increase of T–cell immune response. Moreover, the restoration process of the neurologic functions became quicker. The number of infectious complications, pneumonia particularly, as well as the frequency of lethal outcomes was decreased. (Med. Immunol., 2005, vol.7, № 1, pp. 57562)

Keywords

• acute stroke
• immune status
• cellular immunodeficiency
• roncoleukin