Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity

Tetsuya Kubota; Mariko Inoue; Naoto Kubota; Iseki Takamoto; Tomoka Mineyama; Kaito Iwayama; Kumpei Tokuyama; Masao Moroi; Kohjiro Ueki; Toshimasa Yamauchi; Takashi Kadowaki

doi:10.1038/s41467-018-07358-9

Nature Communications (Nov 2018)

Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity

Tetsuya Kubota,
Mariko Inoue,
Naoto Kubota,
Iseki Takamoto,
Tomoka Mineyama,
Kaito Iwayama,
Kumpei Tokuyama,
Masao Moroi,
Kohjiro Ueki,
Toshimasa Yamauchi,
Takashi Kadowaki

Affiliations

Tetsuya Kubota: Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
Mariko Inoue: Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
Naoto Kubota: Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
Iseki Takamoto: Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
Tomoka Mineyama: Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
Kaito Iwayama: Graduate School of Comprehensive Human Sciences, University of Tsukuba
Kumpei Tokuyama: Graduate School of Comprehensive Human Sciences, University of Tsukuba
Masao Moroi: Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
Kohjiro Ueki: Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
Toshimasa Yamauchi: Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
Takashi Kadowaki: Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-018-07358-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

Read online

Obesity is associated with low-grade chronic inflammation. Here the authors show that the activation of anti-inflammatory M2a-subtype macrophages requires the IL4/Irs2/Akt pathway. Due to decreased Irs2 expression this pathway is impaired in obese mice thus leading to a defect in M2a activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal