Nature Communications (May 2018)
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
- Gail Davies,
- Max Lam,
- Sarah E. Harris,
- Joey W. Trampush,
- Michelle Luciano,
- W. David Hill,
- Saskia P. Hagenaars,
- Stuart J. Ritchie,
- Riccardo E. Marioni,
- Chloe Fawns-Ritchie,
- David C. M. Liewald,
- Judith A. Okely,
- Ari V. Ahola-Olli,
- Catriona L. K. Barnes,
- Lars Bertram,
- Joshua C. Bis,
- Katherine E. Burdick,
- Andrea Christoforou,
- Pamela DeRosse,
- Srdjan Djurovic,
- Thomas Espeseth,
- Stella Giakoumaki,
- Sudheer Giddaluru,
- Daniel E. Gustavson,
- Caroline Hayward,
- Edith Hofer,
- M. Arfan Ikram,
- Robert Karlsson,
- Emma Knowles,
- Jari Lahti,
- Markus Leber,
- Shuo Li,
- Karen A. Mather,
- Ingrid Melle,
- Derek Morris,
- Christopher Oldmeadow,
- Teemu Palviainen,
- Antony Payton,
- Raha Pazoki,
- Katja Petrovic,
- Chandra A. Reynolds,
- Muralidharan Sargurupremraj,
- Markus Scholz,
- Jennifer A. Smith,
- Albert V. Smith,
- Natalie Terzikhan,
- Anbupalam Thalamuthu,
- Stella Trompet,
- Sven J. van der Lee,
- Erin B. Ware,
- B. Gwen Windham,
- Margaret J. Wright,
- Jingyun Yang,
- Jin Yu,
- David Ames,
- Najaf Amin,
- Philippe Amouyel,
- Ole A. Andreassen,
- Nicola J. Armstrong,
- Amelia A. Assareh,
- John R. Attia,
- Deborah Attix,
- Dimitrios Avramopoulos,
- David A. Bennett,
- Anne C. Böhmer,
- Patricia A. Boyle,
- Henry Brodaty,
- Harry Campbell,
- Tyrone D. Cannon,
- Elizabeth T. Cirulli,
- Eliza Congdon,
- Emily Drabant Conley,
- Janie Corley,
- Simon R. Cox,
- Anders M. Dale,
- Abbas Dehghan,
- Danielle Dick,
- Dwight Dickinson,
- Johan G. Eriksson,
- Evangelos Evangelou,
- Jessica D. Faul,
- Ian Ford,
- Nelson A. Freimer,
- He Gao,
- Ina Giegling,
- Nathan A. Gillespie,
- Scott D. Gordon,
- Rebecca F. Gottesman,
- Michael E. Griswold,
- Vilmundur Gudnason,
- Tamara B. Harris,
- Annette M. Hartmann,
- Alex Hatzimanolis,
- Gerardo Heiss,
- Elizabeth G. Holliday,
- Peter K. Joshi,
- Mika Kähönen,
- Sharon L. R. Kardia,
- Ida Karlsson,
- Luca Kleineidam,
- David S. Knopman,
- Nicole A. Kochan,
- Bettina Konte,
- John B. Kwok,
- Stephanie Le Hellard,
- Teresa Lee,
- Terho Lehtimäki,
- Shu-Chen Li,
- Christina M. Lill,
- Tian Liu,
- Marisa Koini,
- Edythe London,
- Will T. Longstreth,
- Oscar L. Lopez,
- Anu Loukola,
- Tobias Luck,
- Astri J. Lundervold,
- Anders Lundquist,
- Leo-Pekka Lyytikäinen,
- Nicholas G. Martin,
- Grant W. Montgomery,
- Alison D. Murray,
- Anna C. Need,
- Raymond Noordam,
- Lars Nyberg,
- William Ollier,
- Goran Papenberg,
- Alison Pattie,
- Ozren Polasek,
- Russell A. Poldrack,
- Bruce M. Psaty,
- Simone Reppermund,
- Steffi G. Riedel-Heller,
- Richard J. Rose,
- Jerome I. Rotter,
- Panos Roussos,
- Suvi P. Rovio,
- Yasaman Saba,
- Fred W. Sabb,
- Perminder S. Sachdev,
- Claudia L. Satizabal,
- Matthias Schmid,
- Rodney J. Scott,
- Matthew A. Scult,
- Jeannette Simino,
- P. Eline Slagboom,
- Nikolaos Smyrnis,
- Aïcha Soumaré,
- Nikos C. Stefanis,
- David J. Stott,
- Richard E. Straub,
- Kjetil Sundet,
- Adele M. Taylor,
- Kent D. Taylor,
- Ioanna Tzoulaki,
- Christophe Tzourio,
- André Uitterlinden,
- Veronique Vitart,
- Aristotle N. Voineskos,
- Jaakko Kaprio,
- Michael Wagner,
- Holger Wagner,
- Leonie Weinhold,
- K. Hoyan Wen,
- Elisabeth Widen,
- Qiong Yang,
- Wei Zhao,
- Hieab H. H. Adams,
- Dan E. Arking,
- Robert M. Bilder,
- Panos Bitsios,
- Eric Boerwinkle,
- Ornit Chiba-Falek,
- Aiden Corvin,
- Philip L. De Jager,
- Stéphanie Debette,
- Gary Donohoe,
- Paul Elliott,
- Annette L. Fitzpatrick,
- Michael Gill,
- David C. Glahn,
- Sara Hägg,
- Narelle K. Hansell,
- Ahmad R. Hariri,
- M. Kamran Ikram,
- J. Wouter Jukema,
- Eero Vuoksimaa,
- Matthew C. Keller,
- William S. Kremen,
- Lenore Launer,
- Ulman Lindenberger,
- Aarno Palotie,
- Nancy L. Pedersen,
- Neil Pendleton,
- David J. Porteous,
- Katri Räikkönen,
- Olli T. Raitakari,
- Alfredo Ramirez,
- Ivar Reinvang,
- Igor Rudan,
- Dan Rujescu,
- Reinhold Schmidt,
- Helena Schmidt,
- Peter W. Schofield,
- Peter R. Schofield,
- John M. Starr,
- Vidar M. Steen,
- Julian N. Trollor,
- Steven T. Turner,
- Cornelia M. Van Duijn,
- Arno Villringer,
- Daniel R. Weinberger,
- David R. Weir,
- James F. Wilson,
- Anil Malhotra,
- Andrew M. McIntosh,
- Catharine R. Gale,
- Sudha Seshadri,
- Thomas H. Mosley,
- Jan Bressler,
- Todd Lencz,
- Ian J. Deary
Affiliations
- Gail Davies
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Max Lam
- Institute of Mental Health
- Sarah E. Harris
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Joey W. Trampush
- BrainWorkup, LLC
- Michelle Luciano
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- W. David Hill
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Saskia P. Hagenaars
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Stuart J. Ritchie
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Riccardo E. Marioni
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Chloe Fawns-Ritchie
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- David C. M. Liewald
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Judith A. Okely
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Ari V. Ahola-Olli
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
- Catriona L. K. Barnes
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place
- Lars Bertram
- Max Planck Institute for Molecular Genetics
- Joshua C. Bis
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Katherine E. Burdick
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Andrea Christoforou
- NORMENT, K.G. Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen
- Pamela DeRosse
- Institute of Mental Health
- Srdjan Djurovic
- NORMENT, K.G. Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen
- Thomas Espeseth
- Department of Psychology, University of Oslo
- Stella Giakoumaki
- Department of Psychology, University of Crete
- Sudheer Giddaluru
- NORMENT, K.G. Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen
- Daniel E. Gustavson
- Department of Psychiatry, University of California
- Caroline Hayward
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Edith Hofer
- Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz
- M. Arfan Ikram
- Department of Epidemiology, Erasmus University Medical Center
- Robert Karlsson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Emma Knowles
- Department of Psychiatry, Yale University School of Medicine
- Jari Lahti
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki
- Markus Leber
- Department of Psychiatry and Psychotherapy, University of Cologne
- Shuo Li
- Department of Biostatistics, Boston University School of Public Health
- Karen A. Mather
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Ingrid Melle
- NORMENT, K.G. Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen
- Derek Morris
- Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway
- Christopher Oldmeadow
- Medical Research Institute and Faculty of Health, University of Newcastle
- Teemu Palviainen
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Antony Payton
- Centre for EpidemiologyDivision of Population Health, Health Services Research & Primary Care, The University of Manchester
- Raha Pazoki
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Katja Petrovic
- Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz
- Chandra A. Reynolds
- Department of Psychology, University of California Riverside
- Muralidharan Sargurupremraj
- University of Bordeaux, Bordeaux Population Health Research Center
- Markus Scholz
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Jennifer A. Smith
- Department of Epidemiology, School of Public Health, University of Michigan
- Albert V. Smith
- Icelandic Heart Association
- Natalie Terzikhan
- Department of Epidemiology, Erasmus University Medical Center
- Anbupalam Thalamuthu
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Stella Trompet
- Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center
- Sven J. van der Lee
- Department of Epidemiology, Erasmus University Medical Center
- Erin B. Ware
- Survey Research Center, Institute for Social Research, University of Michigan
- B. Gwen Windham
- Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center
- Margaret J. Wright
- Queensland Brain Institute, University of Queensland
- Jingyun Yang
- Rush Alzheimer’s Disease Center, Rush University Medical Center
- Jin Yu
- Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research
- David Ames
- National Ageing Research Institute, Royal Melbourne Hospital
- Najaf Amin
- Department of Epidemiology, Erasmus University Medical Center
- Philippe Amouyel
- Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-LabEx DISTALZ
- Ole A. Andreassen
- Department of Psychology, University of Oslo
- Nicola J. Armstrong
- Mathematics and Statistics, Murdoch University
- Amelia A. Assareh
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- John R. Attia
- Hunter Medical Research Institute and Faculty of Health, University of Newcastle
- Deborah Attix
- Department of NeurologyBryan Alzheimer’s Disease Research Center, and Center for Genomic and Computational Biology, Duke University Medical Center
- Dimitrios Avramopoulos
- Department of Psychiatry, Johns Hopkins University School of Medicine
- David A. Bennett
- Rush Alzheimer’s Disease Center, Rush University Medical Center
- Anne C. Böhmer
- Institute of Human Genetics, University of Bonn
- Patricia A. Boyle
- Rush Alzheimer’s Disease Center, Rush University Medical Center
- Henry Brodaty
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Harry Campbell
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place
- Tyrone D. Cannon
- Department of Psychology, Yale University
- Elizabeth T. Cirulli
- Human Longevity Inc
- Eliza Congdon
- UCLA Semel Institute for Neuroscience and Human Behavior
- Emily Drabant Conley
- 23andMe, Inc.
- Janie Corley
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Simon R. Cox
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Anders M. Dale
- Department of Psychiatry, University of California
- Abbas Dehghan
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Danielle Dick
- Department of Psychology, Virginia Commonwealth University
- Dwight Dickinson
- Clinical and Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institute of Health
- Johan G. Eriksson
- National Institute for Health and Welfare
- Evangelos Evangelou
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Jessica D. Faul
- Survey Research Center, Institute for Social Research, University of Michigan
- Ian Ford
- Robertson Centre for Biostatistics, University of Glasgow
- Nelson A. Freimer
- UCLA Semel Institute for Neuroscience and Human Behavior
- He Gao
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Ina Giegling
- Department of Psychiatry, Martin Luther University of Halle-Wittenberg
- Nathan A. Gillespie
- Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University
- Scott D. Gordon
- QIMR Berghofer Medical Research Institute
- Rebecca F. Gottesman
- Department of Neurology, Johns Hopkins University School of Medicine
- Michael E. Griswold
- Department of Data Science, University of Mississippi Medical Center
- Vilmundur Gudnason
- Icelandic Heart Association
- Tamara B. Harris
- Intramural Research Program National Institutes on Aging, National Institutes of Health
- Annette M. Hartmann
- Department of Psychiatry, Martin Luther University of Halle-Wittenberg
- Alex Hatzimanolis
- Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital
- Gerardo Heiss
- Department of Epidemiology, University of North Carolina Gillings School of Global Public Health
- Elizabeth G. Holliday
- Hunter Medical Research Institute and Faculty of Health, University of Newcastle
- Peter K. Joshi
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place
- Mika Kähönen
- Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center
- Sharon L. R. Kardia
- Department of Epidemiology, School of Public Health, University of Michigan
- Ida Karlsson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Luca Kleineidam
- Department of Psychiatry Medical Faculty, University of Cologne
- David S. Knopman
- Department of Neurology, Mayo Clinic
- Nicole A. Kochan
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Bettina Konte
- Department of Psychiatry, Martin Luther University of Halle-Wittenberg
- John B. Kwok
- Brain and Mind Centre—The University of Sydney
- Stephanie Le Hellard
- NORMENT, K.G. Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen
- Teresa Lee
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories, Finnish Cardiovascular Research Center—Tampere, Faculty of Medicine and Life Sciences, University of Tampere
- Shu-Chen Li
- Max Planck Institute for Human Development
- Christina M. Lill
- Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, University of Lübeck
- Tian Liu
- Max Planck Institute for Molecular Genetics
- Marisa Koini
- Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz
- Edythe London
- UCLA Semel Institute for Neuroscience and Human Behavior
- Will T. Longstreth
- Department of Neurology, School of Medicine, University of Washington
- Oscar L. Lopez
- Department of Neurology and Psychiatry, University of Pittsburgh
- Anu Loukola
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Tobias Luck
- LIFE—Leipzig Research Center for Civilization Diseases, University of Leipzig
- Astri J. Lundervold
- Department of Biological and Medical Psychology, University of Bergen
- Anders Lundquist
- Umeå Center for Functional Brain Imaging (UFBI), Umeå University
- Leo-Pekka Lyytikäinen
- Department of Clinical Chemistry, Fimlab Laboratories, Finnish Cardiovascular Research Center—Tampere, Faculty of Medicine and Life Sciences, University of Tampere
- Nicholas G. Martin
- QIMR Berghofer Medical Research Institute
- Grant W. Montgomery
- QIMR Berghofer Medical Research Institute
- Alison D. Murray
- Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh
- Anna C. Need
- Division of Brain Sciences, Department of Medicine, Imperial College
- Raymond Noordam
- Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center
- Lars Nyberg
- Umeå Center for Functional Brain Imaging (UFBI), Umeå University
- William Ollier
- Centre for Integrated Genomic Medical Research, Institute of Population Health, University of Manchester
- Goran Papenberg
- Max Planck Institute for Human Development
- Alison Pattie
- Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Ozren Polasek
- Gen-Info LLC
- Russell A. Poldrack
- Department of Psychology, Stanford University
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Simone Reppermund
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Steffi G. Riedel-Heller
- Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig
- Richard J. Rose
- Department of Psychological and Brain Sciences, Indiana University
- Jerome I. Rotter
- Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Panos Roussos
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Suvi P. Rovio
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
- Yasaman Saba
- Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz
- Fred W. Sabb
- Robert and Beverly Lewis Center for Neuroimaging, University of Oregon
- Perminder S. Sachdev
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Claudia L. Satizabal
- Department of Neurology, Boston University School of Medicine
- Matthias Schmid
- Department of Medical Biometry, Informatics and Epidemiology, University Hospital
- Rodney J. Scott
- Hunter Medical Research Institute and Faculty of Health, University of Newcastle
- Matthew A. Scult
- Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University
- Jeannette Simino
- Department of Data Science, University of Mississippi Medical Center
- P. Eline Slagboom
- Department of Molecular Epidemiology, Leiden University Medical Center
- Nikolaos Smyrnis
- Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital
- Aïcha Soumaré
- University of Bordeaux, Bordeaux Population Health Research Center
- Nikos C. Stefanis
- Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital
- David J. Stott
- Institute of Cardiovascular and Medical Sciences, University of Glasgow
- Richard E. Straub
- Lieber Institute for Brain Development, Johns Hopkins University Medical Campus
- Kjetil Sundet
- Department of Psychology, University of Oslo
- Adele M. Taylor
- Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Kent D. Taylor
- Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Ioanna Tzoulaki
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Christophe Tzourio
- University of Bordeaux, Bordeaux Population Health Research Center
- André Uitterlinden
- Department of Epidemiology, Erasmus University Medical Center
- Veronique Vitart
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Aristotle N. Voineskos
- Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, University of Toronto
- Jaakko Kaprio
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Michael Wagner
- German Center for Neurodegenerative Diseases (DZNE)
- Holger Wagner
- Department of Psychiatry and Psychotherapy, University of Bonn
- Leonie Weinhold
- Department of Medical Biometry, Informatics and Epidemiology, University Hospital
- K. Hoyan Wen
- Department of Epidemiology, Erasmus University Medical Center
- Elisabeth Widen
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Qiong Yang
- Department of Biostatistics, Boston University School of Public Health
- Wei Zhao
- Department of Epidemiology, School of Public Health, University of Michigan
- Hieab H. H. Adams
- Department of Epidemiology, Erasmus University Medical Center
- Dan E. Arking
- McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
- Robert M. Bilder
- UCLA Semel Institute for Neuroscience and Human Behavior
- Panos Bitsios
- Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete
- Eric Boerwinkle
- Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston
- Ornit Chiba-Falek
- Department of NeurologyBryan Alzheimer’s Disease Research Center, and Center for Genomic and Computational Biology, Duke University Medical Center
- Aiden Corvin
- Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin
- Philip L. De Jager
- Center for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center
- Stéphanie Debette
- University of Bordeaux, Bordeaux Population Health Research Center
- Gary Donohoe
- Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway
- Paul Elliott
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Annette L. Fitzpatrick
- Department of Epidemiology, University of Washington
- Michael Gill
- Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin
- David C. Glahn
- Department of Psychiatry, Yale University School of Medicine
- Sara Hägg
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Narelle K. Hansell
- Queensland Brain Institute, University of Queensland
- Ahmad R. Hariri
- Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University
- M. Kamran Ikram
- Department of Epidemiology, Erasmus University Medical Center
- J. Wouter Jukema
- Department of Cardiology, Leiden University Medical Center
- Eero Vuoksimaa
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Matthew C. Keller
- Institute for Behavioral Genetics, University of Colorado
- William S. Kremen
- Department of Psychiatry, University of California
- Lenore Launer
- Intramural Research Program National Institutes on Aging, National Institutes of Health
- Ulman Lindenberger
- Max Planck Institute for Human Development
- Aarno Palotie
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki
- Nancy L. Pedersen
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Neil Pendleton
- Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Manchester Academic Health Science Centre, and Manchester Medical School, Institute of Brain, Behaviour, and Mental Health, University of Manchester
- David J. Porteous
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Katri Räikkönen
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki
- Olli T. Raitakari
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
- Alfredo Ramirez
- Department of Psychiatry and Psychotherapy, University of Cologne
- Ivar Reinvang
- Division of Mental Health and Addiction, Oslo University Hospital
- Igor Rudan
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place
- Dan Rujescu
- Department of Psychiatry, Martin Luther University of Halle-Wittenberg
- Reinhold Schmidt
- Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz
- Helena Schmidt
- Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz
- Peter W. Schofield
- School of Medicine and Public Health, University of Newcastle
- Peter R. Schofield
- Neuroscience Research Australia
- John M. Starr
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Vidar M. Steen
- NORMENT, K.G. Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen
- Julian N. Trollor
- Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales
- Steven T. Turner
- Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic
- Cornelia M. Van Duijn
- Department of Epidemiology, Erasmus University Medical Center
- Arno Villringer
- Max Planck Institute for Human Cognitive and Brain Sciences
- Daniel R. Weinberger
- Lieber Institute for Brain Development, Johns Hopkins University Medical Campus
- David R. Weir
- Survey Research Center, Institute for Social Research, University of Michigan
- James F. Wilson
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place
- Anil Malhotra
- Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research
- Andrew M. McIntosh
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Catharine R. Gale
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- Sudha Seshadri
- Robert and Beverly Lewis Center for Neuroimaging, University of Oregon
- Thomas H. Mosley
- Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center
- Jan Bressler
- Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston
- Todd Lencz
- Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research
- Ian J. Deary
- Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh
- DOI
- https://doi.org/10.1038/s41467-018-04362-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Cognitive function is associated with health and important life outcomes. Here, the authors perform a genome-wide association study for general cognitive function in 300,486 individuals and identify genetic loci that implicate neural and cell developmental pathways in this trait.
