S-acylation of P2K1 mediates extracellular ATP-induced immune signaling in Arabidopsis

Abstract

S-acylation is a reversible protein post-translational modification that often regulates protein function at the plasma membrane. Here the authors show that an Arabidopsis extracellular ATP receptor P2K1 mediates phosphorylation of two S-acyltransferases which in turn mediate S-acylation of P2K1 and dampen ATP responses.