Nature Communications (Oct 2016)
Mitochondrial function controls intestinal epithelial stemness and proliferation
- Emanuel Berger,
- Eva Rath,
- Detian Yuan,
- Nadine Waldschmitt,
- Sevana Khaloian,
- Michael Allgäuer,
- Ori Staszewski,
- Elena M. Lobner,
- Theresa Schöttl,
- Pieter Giesbertz,
- Olivia I. Coleman,
- Marco Prinz,
- Achim Weber,
- Markus Gerhard,
- Martin Klingenspor,
- Klaus-Peter Janssen,
- Mathias Heikenwalder,
- Dirk Haller
Affiliations
- Emanuel Berger
- Technische Universität München, Chair of Nutrition and Immunology
- Eva Rath
- Technische Universität München, Chair of Nutrition and Immunology
- Detian Yuan
- Helmholtz-Zentrum München, Institute of Virology
- Nadine Waldschmitt
- Technische Universität München, Chair of Nutrition and Immunology
- Sevana Khaloian
- Technische Universität München, Chair of Nutrition and Immunology
- Michael Allgäuer
- Technische Universität München, Institute of Medical Microbiology, Immunology and Hygiene
- Ori Staszewski
- University of Freiburg, Institute of Neuropathology
- Elena M. Lobner
- Technische Universität München, Chair of Nutrition and Immunology
- Theresa Schöttl
- Technische Universität München, Chair of Molecular Nutritional Medicine, Else Kröner-Fresenius Center
- Pieter Giesbertz
- Department of Nutritional Physiology, Technische Universität München
- Olivia I. Coleman
- Technische Universität München, Chair of Nutrition and Immunology
- Marco Prinz
- University of Freiburg, Institute of Neuropathology
- Achim Weber
- University Hospital Zurich, Institute of Surgical Pathology
- Markus Gerhard
- Technische Universität München, Institute of Medical Microbiology, Immunology and Hygiene
- Martin Klingenspor
- Technische Universität München, Chair of Molecular Nutritional Medicine, Else Kröner-Fresenius Center
- Klaus-Peter Janssen
- Department of Surgery, Technische Universität München
- Mathias Heikenwalder
- Helmholtz-Zentrum München, Institute of Virology
- Dirk Haller
- Technische Universität München, Chair of Nutrition and Immunology
- DOI
- https://doi.org/10.1038/ncomms13171
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 17
Abstract
It is unclear what role mitochondrial function plays in maintaining intestinal epithelial cell (IEC) homeostasis. Here, the authors deplete a mitochondrial chaperone, heat shock protein 60 (HSP60) in IEC and observe a loss of stemness and cell proliferation, and suggest this is accompanied by a compensatory release of WNT-related factors.
