Emerging Infectious Diseases (Feb 2022)

SARS-CoV-2 Cross-Reactivity in Prepandemic Serum from Rural Malaria-Infected Persons, Cambodia

  • Jessica Manning,
  • Irfan Zaidi,
  • Chanthap Lon,
  • Luz Angela Rosas,
  • Jae-Keun Park,
  • Aiyana Ponce,
  • Jennifer Bohl,
  • Sophana Chea,
  • Maria Karkanitsa,
  • Sokunthea Sreng,
  • Huy Rekol,
  • Char Meng Chour,
  • Dominic Esposito,
  • Jeffery K. Taubenberger,
  • Matthew J. Memoli,
  • Kaitlyn Sadtler,
  • Patrick E. Duffy,
  • Fabiano Oliveira

DOI
https://doi.org/10.3201/eid2802.211725
Journal volume & issue
Vol. 28, no. 2
pp. 440 – 444

Abstract

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Inhabitants of the Greater Mekong Subregion in Cambodia are exposed to pathogens that might influence serologic cross-reactivity with severe acute respiratory syndrome coronavirus 2. A prepandemic serosurvey of 528 malaria-infected persons demonstrated higher-than-expected positivity of nonneutralizing IgG to spike and receptor-binding domain antigens. These findings could affect interpretation of large-scale serosurveys.

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