Mathematical formalism of femtosecond laser-deoxyribonucleic acid interaction: thermal evolution
Mihai Oane,
Bogdan A. Sava,
Muhammad Arif Mahmood,
Natalia Mihailescu,
Sinziana Anghel,
Ana V. Filip,
Ion N. Mihailescu,
Cristian N. Mihailescu,
Carmen Ristoscu
Affiliations
Mihai Oane
National Institute for Laser, Plasma and Radiation Physics (INFLPR), Magurele, Ilfov 077125, Romania
Bogdan A. Sava
National Institute for Laser, Plasma and Radiation Physics (INFLPR), Magurele, Ilfov 077125, Romania; University Politehnica of Bucharest, Bucharest, Romania
Muhammad Arif Mahmood
Mechanical Engineering Program, Texas A&M University at Qatar, P.O. Box 23874, Doha, Qatar
Natalia Mihailescu
National Institute for Laser, Plasma and Radiation Physics (INFLPR), Magurele, Ilfov 077125, Romania
Sinziana Anghel
National Institute for Laser, Plasma and Radiation Physics (INFLPR), Magurele, Ilfov 077125, Romania; University of Bucharest, Faculty of Physics, RO-077125 Magurele, Ilfov, Romania
Ana V. Filip
National Institute for Laser, Plasma and Radiation Physics (INFLPR), Magurele, Ilfov 077125, Romania
Ion N. Mihailescu
National Institute for Laser, Plasma and Radiation Physics (INFLPR), Magurele, Ilfov 077125, Romania
Cristian N. Mihailescu
National Institute for Laser, Plasma and Radiation Physics (INFLPR), Magurele, Ilfov 077125, Romania
Carmen Ristoscu
National Institute for Laser, Plasma and Radiation Physics (INFLPR), Magurele, Ilfov 077125, Romania; Corresponding author.
A novel analytical formalism is proposed based upon Quantum heat transport equation in order to describe the femtoseconds/picoseconds laser pulses interaction with the Deoxyribonucleic acid (DNA). The formalism generates solutions based upon inputs as: voltage, laser beam intensity and laser - DNA interaction time. Thermal waves induced inside irradiated DNA are defined and accounted for. Analytical simulations show that the optimum regime of laser - DNA interaction was reached for a potential carrier generated at the interface equal to 3.5 × 10−3 eV. It has to be mentioned that the formalism breaks down if the potential carrier generated at the interface is inferior to 10−2 eV. Accordingly, for pulse duration inferior to 1 ps, the laser beam spatial-temporal distribution has an essential role in defining the shape and magnitude of the thermal distribution within the irradiated DNA strands.
