Communications Biology (Oct 2022)
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease
- Priyanka Baloni,
- Matthias Arnold,
- Luna Buitrago,
- Kwangsik Nho,
- Herman Moreno,
- Kevin Huynh,
- Barbara Brauner,
- Gregory Louie,
- Alexandra Kueider-Paisley,
- Karsten Suhre,
- Andrew J. Saykin,
- Kim Ekroos,
- Peter J. Meikle,
- Leroy Hood,
- Nathan D. Price,
- The Alzheimer’s Disease Metabolomics Consortium,
- P. Murali Doraiswamy,
- Cory C. Funk,
- A. Iván Hernández,
- Gabi Kastenmüller,
- Rebecca Baillie,
- Xianlin Han,
- Rima Kaddurah-Daouk
Affiliations
- Priyanka Baloni
- Institute for Systems Biology
- Matthias Arnold
- Institute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health
- Luna Buitrago
- Department of Neurology/Pharmacology, SUNY Downstate Medical Center
- Kwangsik Nho
- Indiana Alzheimer’s Disease Research Center and Department of Radiology and Imaging Sciences, Indiana University School of Medicine
- Herman Moreno
- Department of Neurology/Pharmacology, SUNY Downstate Medical Center
- Kevin Huynh
- Metabolomics Laboratory, Baker Heart and Diabetes Institute
- Barbara Brauner
- Institute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health
- Gregory Louie
- Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham
- Alexandra Kueider-Paisley
- Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham
- Karsten Suhre
- Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City
- Andrew J. Saykin
- Indiana Alzheimer’s Disease Research Center and Department of Radiology and Imaging Sciences, Indiana University School of Medicine
- Kim Ekroos
- Lipidomics Consulting Ltd.
- Peter J. Meikle
- Metabolomics Laboratory, Baker Heart and Diabetes Institute
- Leroy Hood
- Institute for Systems Biology
- Nathan D. Price
- Institute for Systems Biology
- The Alzheimer’s Disease Metabolomics Consortium
- P. Murali Doraiswamy
- Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham
- Cory C. Funk
- Institute for Systems Biology
- A. Iván Hernández
- Department of Pathology, SUNY Downstate Medical Center
- Gabi Kastenmüller
- Institute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health
- Rebecca Baillie
- Rosa & Co LLC
- Xianlin Han
- University of Texas Health Science Center at San Antonio
- Rima Kaddurah-Daouk
- Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham
- DOI
- https://doi.org/10.1038/s42003-022-04011-6
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
Complementary multi-omics approach, in silico metabolic flux, and neuroimaging analyses link the sphingolipid pathway to Alzheimer’s disease pathogenesis with therapeutic targets validated using behavioral assessments in amyloidogenic APP/PS1 mice.
