Reductive amination with zinc powder in aqueous media

Giovanni B. Giovenzana; Daniela Imperio; Andrea Penoni; Giovanni Palmisano

doi:10.3762/bjoc.7.125

Beilstein Journal of Organic Chemistry (Aug 2011)

Reductive amination with zinc powder in aqueous media

Giovanni B. Giovenzana,
Daniela Imperio,
Andrea Penoni,
Giovanni Palmisano

Affiliations

Giovanni B. Giovenzana: DiSCAFF, Università degli Studi del Piemonte Orientale “A. Avogadro”, Via Bovio 6, I-28100 Novara, Italy; Fax: +39-(0)321-375821, Tel: +39-(0)321-375846
Daniela Imperio: DiSCAFF, Università degli Studi del Piemonte Orientale “A. Avogadro”, Via Bovio 6, I-28100 Novara, Italy; Fax: +39-(0)321-375821, Tel: +39-(0)321-375846
Andrea Penoni: Dipartimento di Scienze Chimiche e Ambientali, Università dell’Insubria, Via Valleggio 11, I-22100 Como, Italy; Fax: +39-(0)31-2386449, Tel: +39-(0)31-2386234
Giovanni Palmisano: Dipartimento di Scienze Chimiche e Ambientali, Università dell’Insubria, Via Valleggio 11, I-22100 Como, Italy; Fax: +39-(0)31-2386449, Tel: +39-(0)31-2386234

DOI: https://doi.org/10.3762/bjoc.7.125
Journal volume & issue: Vol. 7, no. 1
pp. 1095 – 1099

Abstract

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Zinc powder in aqueous alkaline media was employed to perform reductive amination of aldehydes with primary amines. The corresponding secondary amines were obtained in good yields along with minor amounts of hydrodimerization byproducts. The protocol is a green alternative to the use of complex hydrides in chlorinated or highly flammable solvents.

Published in Beilstein Journal of Organic Chemistry

ISSN: 1860-5397 (Online)
Publisher: Beilstein-Institut
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.beilstein-journals.org/bjoc

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