CORRELATIONS BETWEEN HEALING PARAMETERS AND PGE2 EXPRESSION LEVELS IN NON-SURGICAL THERAPY OF CHRONIC PERIODONTITIS

Abstract

Background: The effectiveness and limitations of causal therapy of chronic periodontitis have been thoroughly documented in the literature, and the intensity of the individual destructive host response is taken into consideration, as well. These facts are the basis in research of additional therapeutic approaches to modify tissue response by regulating the amount and activity of pro-inflammatory mediators and those of destruction. Various drugs are being studied to modulate the host's response in chronic periodontitis. The use of non-steroidal anti-inflammatory drugs that inhibit the expression and activity of important mediators has led to positive results. Aim: To assess changes in PGE2 gene expression levels as a result of non-surgical therapy and additional application of a non-steroidal anti-inflammatory agent in chronic periodontitis. Material and methods: Thirty patients with moderate to severe periodontitis without systemic diseases were involved in the study. Clinical and laboratory methods were used to evaluate non-surgical periodontal treatment. Results: The data obtained from the clinical measurements - PD, CAL, BL and BOP shows that no statistically reliable relationship between gene expression of PGE2 and most clinical parameters was found in the control and test groups. Reduction in the values following the therapy was recorded in a lot of patients, but only in the test group (taking NSAIDs) with a pocket depth (PD) ≥5mm a statistically significant, inverse correlation between the PGE2 gene expression levels and changes in the pocket depth was established. Conclusion: Additional therapy with NSAIDs in chronic periodontitis has higher efficacy, manifested by correlation of deep pockets reduction and changes in PGE2 expression.

Keywords

• chronic periodontitis
• host response
• non-surgical therapy (SRP)
• NSAIDs
• pro-inflammatory mediators