Antimicrobial Resistance Surveillance: Data Harmonisation and Data Selection within Secondary Data Use
Sinja Bleischwitz,
Tristan Salomon Winkelmann,
Yvonne Pfeifer,
Martin Alexander Fischer,
Niels Pfennigwerth,
Jens André Hammerl,
Ulrike Binsker,
Jörg B. Hans,
Sören Gatermann,
Annemarie Käsbohrer,
Guido Werner,
Lothar Kreienbrock
Affiliations
Sinja Bleischwitz
Department of Biometry, Epidemiology and Information Processing, WHO Collaborating Centre for Research and Training for Health in the Human-Animal-Environment Interface, University for Veterinary Medicine, 30559 Hanover, Germany
Tristan Salomon Winkelmann
Department of Biometry, Epidemiology and Information Processing, WHO Collaborating Centre for Research and Training for Health in the Human-Animal-Environment Interface, University for Veterinary Medicine, 30559 Hanover, Germany
Yvonne Pfeifer
Department of Infectious Diseases, Division of Nosocomial Pathogens and Antimicrobial Resistances, Robert Koch Institute, 38855 Wernigerode, Germany
Martin Alexander Fischer
Department of Infectious Diseases, Division of Nosocomial Pathogens and Antimicrobial Resistances, Robert Koch Institute, 38855 Wernigerode, Germany
Niels Pfennigwerth
National Reference Centre for Multidrug-Resistant Gram-Negative Bacteria, Department Medical Microbiology, Ruhr-University Bochum, 44801 Bochum, Germany
Jens André Hammerl
Division of Epidemiology, Zoonoses and Antimicrobial Resistance, Department Biological Safety, Federal Institute for Risk Assessment, 12277 Berlin, Germany
Ulrike Binsker
Division of Epidemiology, Zoonoses and Antimicrobial Resistance, Department Biological Safety, Federal Institute for Risk Assessment, 12277 Berlin, Germany
Jörg B. Hans
National Reference Centre for Multidrug-Resistant Gram-Negative Bacteria, Department Medical Microbiology, Ruhr-University Bochum, 44801 Bochum, Germany
Sören Gatermann
National Reference Centre for Multidrug-Resistant Gram-Negative Bacteria, Department Medical Microbiology, Ruhr-University Bochum, 44801 Bochum, Germany
Annemarie Käsbohrer
Division of Epidemiology, Zoonoses and Antimicrobial Resistance, Department Biological Safety, Federal Institute for Risk Assessment, 12277 Berlin, Germany
Guido Werner
Department of Infectious Diseases, Division of Nosocomial Pathogens and Antimicrobial Resistances, Robert Koch Institute, 38855 Wernigerode, Germany
Lothar Kreienbrock
Department of Biometry, Epidemiology and Information Processing, WHO Collaborating Centre for Research and Training for Health in the Human-Animal-Environment Interface, University for Veterinary Medicine, 30559 Hanover, Germany
Resistance to last-resort antibiotics is a global threat to public health. Therefore, surveillance and monitoring systems for antimicrobial resistance should be established on a national and international scale. For the development of a One Health surveillance system, we collected exemplary data on carbapenem and colistin-resistant bacterial isolates from human, animal, food, and environmental sources. We pooled secondary data from routine screenings, hospital outbreak investigations, and studies on antimicrobial resistance. For a joint One Health evaluation, this study incorporates epidemiological metadata with phenotypic resistance information and molecular data on the isolate level. To harmonise the heterogeneous original information for the intended use, we developed a generic strategy. By defining and categorising variables, followed by plausibility checks, we created a catalogue for prospective data collections and applied it to our dataset, enabling us to perform preliminary descriptive statistical analyses. This study shows the complexity of data management using heterogeneous secondary data pools and gives an insight into the early stages of the development of an AMR surveillance programme using secondary data.
