Nature Communications (Sep 2018)
Microbial metabolite sensor GPR43 controls severity of experimental GVHD
- Hideaki Fujiwara,
- Melissa D. Docampo,
- Mary Riwes,
- Daniel Peltier,
- Tomomi Toubai,
- Israel Henig,
- S. Julia Wu,
- Stephanie Kim,
- Austin Taylor,
- Stuart Brabbs,
- Chen Liu,
- Cynthia Zajac,
- Katherine Oravecz-Wilson,
- Yaping Sun,
- Gabriel Núñez,
- John E. Levine,
- Marcel R.M. van den Brink,
- James L. M. Ferrara,
- Pavan Reddy
Affiliations
- Hideaki Fujiwara
- Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center
- Melissa D. Docampo
- Department of Immunology, Memorial Sloan Kettering Cancer Center
- Mary Riwes
- Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center
- Daniel Peltier
- Division of Hematology and Oncology, Department of Pediatrics, University of Michigan
- Tomomi Toubai
- Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center
- Israel Henig
- Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center
- S. Julia Wu
- Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center
- Stephanie Kim
- Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center
- Austin Taylor
- Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center
- Stuart Brabbs
- Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center
- Chen Liu
- Department of Pathology and Laboratory Medicine, Rutgers-Robert Wood Johnson Medical School
- Cynthia Zajac
- Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center
- Katherine Oravecz-Wilson
- Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center
- Yaping Sun
- Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center
- Gabriel Núñez
- Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School
- John E. Levine
- Tisch Cancer Institute, the Icahn School of Medicine at Mount Sinai
- Marcel R.M. van den Brink
- Department of Immunology, Memorial Sloan Kettering Cancer Center
- James L. M. Ferrara
- Tisch Cancer Institute, the Icahn School of Medicine at Mount Sinai
- Pavan Reddy
- Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-06048-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
The microbial metabolite sensor GPR43 has been previously shown to be a crucial modulator of immune responses. Here the authors show GPR43 is required for controlling disease pathology severity in the context of experimental models of GVHD.
