Communications Biology (Apr 2021)
SARS-CoV-2 shifting transmission dynamics and hidden reservoirs potentially limit efficacy of public health interventions in Italy
- Marta Giovanetti,
- Eleonora Cella,
- Francesca Benedetti,
- Brittany Rife Magalis,
- Vagner Fonseca,
- Silvia Fabris,
- Giovanni Campisi,
- Alessandra Ciccozzi,
- Silvia Angeletti,
- Alessandra Borsetti,
- Vittoradolfo Tambone,
- Caterina Sagnelli,
- Stefano Pascarella,
- Alberto Riva,
- Giancarlo Ceccarelli,
- Alessandro Marcello,
- Taj Azarian,
- Eduan Wilkinson,
- Tulio de Oliveira,
- Luiz Carlos Junior Alcantara,
- Roberto Cauda,
- Arnaldo Caruso,
- Natalie E. Dean,
- Cameron Browne,
- Jose Lourenco,
- Marco Salemi,
- Davide Zella,
- Massimo Ciccozzi
Affiliations
- Marta Giovanetti
- Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz
- Eleonora Cella
- Burnett School of Biomedical Sciences, University of Central Florida
- Francesca Benedetti
- Institute of Human Virology and Global Virus Network Center, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine
- Brittany Rife Magalis
- Emerging Pathogens Institute & Department of Pathology, College of Medicine, University of Florida
- Vagner Fonseca
- Laboratório de Genética Celular e Molecular, ICB, Universidade Federal de Minas Gerais
- Silvia Fabris
- Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus
- Giovanni Campisi
- Department of Molecular and Translational Medicine, Section of Microbiology, University of Brescia
- Alessandra Ciccozzi
- Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus
- Silvia Angeletti
- Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome
- Alessandra Borsetti
- National HIV/AIDS Researh Center, Istituto Superiore di Sanità
- Vittoradolfo Tambone
- Anthropology, and Applied Ethics, Campus Bio-Medico University
- Caterina Sagnelli
- Department of Mental Health and Public Medicine, University of Campania “Luigi Vanvitelli”
- Stefano Pascarella
- Department of Biochemical Sciences “A. Rossi Fanelli”, University of Rome “La Sapienza”
- Alberto Riva
- ICBR, University of Florida
- Giancarlo Ceccarelli
- Department of Public Health and Infectious Diseases, Policlinico Umberto I Università ‘Sapienza’
- Alessandro Marcello
- Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Taj Azarian
- Burnett School of Biomedical Sciences, University of Central Florida
- Eduan Wilkinson
- KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal
- Tulio de Oliveira
- KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal
- Luiz Carlos Junior Alcantara
- Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz
- Roberto Cauda
- Department Infectious Diseases, – Fondazione Policlinico Universitario “A. Gemelli” IRCCS
- Arnaldo Caruso
- Department of Molecular and Translational Medicine, Section of Microbiology, University of Brescia
- Natalie E. Dean
- Department of Epidemiology, College of Public Health and Health Professions, University of Florida
- Cameron Browne
- Department of Mathematics, University of Lafayette
- Jose Lourenco
- Department of Zoology, University of Oxford
- Marco Salemi
- Emerging Pathogens Institute & Department of Pathology, College of Medicine, University of Florida
- Davide Zella
- Institute of Human Virology and Global Virus Network Center, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine
- Massimo Ciccozzi
- Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus
- DOI
- https://doi.org/10.1038/s42003-021-02025-0
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 9
Abstract
Giovanetti et al. examine SARS-CoV-2 transmission dynamics in Italy using phylodynamic analysis of viral genetic and epidemiological data. They present evidence to suggest that the efficacy of public health interventions is limited by the size and structure of epidemic reservoirs, which may influence vaccination programmes.
