Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis

Wei Xu; Priya Luthra; Chao Wu; Jyoti Batra; Daisy W. Leung; Christopher F. Basler; Gaya K. Amarasinghe

doi:10.1038/ncomms15576

Nature Communications (Jun 2017)

Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis

Wei Xu,
Priya Luthra,
Chao Wu,
Jyoti Batra,
Daisy W. Leung,
Christopher F. Basler,
Gaya K. Amarasinghe

Affiliations

Wei Xu: Department of Pathology and Immunology, Washington University School of Medicine
Priya Luthra: Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University
Chao Wu: Department of Pathology and Immunology, Washington University School of Medicine
Jyoti Batra: Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University
Daisy W. Leung: Department of Pathology and Immunology, Washington University School of Medicine
Christopher F. Basler: Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University
Gaya K. Amarasinghe: Department of Pathology and Immunology, Washington University School of Medicine

DOI: https://doi.org/10.1038/ncomms15576
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

Read online

Ebola virus (EBOV) VP30 is a multifunctional protein that plays a role in transcription, but molecular details remain unknown. Here, using X-ray crystallography and minigenome assays, Xuet al. define the interaction between VP30 and a portion of NP that is critical for optimal EBOV RNA synthesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal