Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases

Abstract

High levels of homocysteine in cells are linked to pathological states. Here, the authors report that homocysteine inactivates catalase by modifying the heme group, impairing cellular redox homeostasis, and show that this modification occurs in cancer cells and in a cellular model of Parkinson’s disease.