Diabetes, Metabolic Syndrome and Obesity (Oct 2023)

Association of Subclinical Hypothyroidism with Type 2 Diabetes Mellitus in Qatar: A Cross-Sectional Study

  • Fakhroo A,
  • Elhadary MR,
  • Elsayed B,
  • Al-Kuwari A,
  • Aly R,
  • Mesilhy R,
  • Bakalaf A,
  • Al-Maadhadi M,
  • Al-Dehaimi AA,
  • Chivese T,
  • Rathnaiah Babu G

Journal volume & issue
Vol. Volume 16
pp. 3373 – 3379

Abstract

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AlMaha Fakhroo,1,* Mohamed Ragab Elhadary,1,* Basel Elsayed,1 Alreem Al-Kuwari,1 Roaa Aly,1 Rowan Mesilhy,1 Amena Bakalaf,1 Mazyona Al-Maadhadi,1 Albandare A Al-Dehaimi,1 Tawanda Chivese,2 Giridhara Rathnaiah Babu2 1College of Medicine, QU Health, Qatar University, Doha, 2713, Qatar; 2Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, 2713, Qatar*These authors contributed equally to this workCorrespondence: Giridhara Rathnaiah Babu, Professor of Global health, Department of population medicine, College of Medicine, P.O. Box 2713, Doha, Qatar, Tel +974 4403 7856, Email [email protected]: The relationship between subclinical hypothyroidism and type 2 diabetes mellitus (T2DM) in Qatar is under-studied, despite the high prevalence of diabetes in the region. This study evaluates the potential association between subclinical hypothyroidism and T2DM in Qatar.Patients and Methods: A cross-sectional study used participants with and without T2DM from the Qatar Biobank (QBB). Logistic regression analysis was used to assess the association between subclinical hypothyroidism and T2DM, with multivariable logistic regression used to adjust for potential confounders.Results: The study found that subclinical hypothyroidism was significantly associated with a 2.82 increase in the odds of having T2DM (OR=2.82, 95% CI (1.13, 7.02), p=0.026) after adjusting for potential confounders. The proportion of subclinical hypothyroidism among individuals with T2DM in Qatar was 4.6%, significantly higher than in those without T2DM (2.8%, p=0.18).Conclusion: This study demonstrates a significant association between subclinical hypothyroidism and T2DM in Qatar. Further research is required to investigate the directionality of this association and its clinical implications.Keywords: cross-sectional, diabetes, hypothyroidism, subclinical hypothyroidism, T2DM

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