Nature Communications (Jan 2023)
Epigenomic charting and functional annotation of risk loci in renal cell carcinoma
- Amin H. Nassar,
- Sarah Abou Alaiwi,
- Sylvan C. Baca,
- Elio Adib,
- Rosario I. Corona,
- Ji-Heui Seo,
- Marcos A. S. Fonseca,
- Sandor Spisak,
- Talal El Zarif,
- Viktoria Tisza,
- David A. Braun,
- Heng Du,
- Monica He,
- Abdallah Flaifel,
- Michel Alchoueiry,
- Thomas Denize,
- Sayed G. Matar,
- Andres Acosta,
- Sachet Shukla,
- Yue Hou,
- John Steinharter,
- Gabrielle Bouchard,
- Jacob E. Berchuck,
- Edward O’Connor,
- Connor Bell,
- Pier Vitale Nuzzo,
- Gwo-Shu Mary Lee,
- Sabina Signoretti,
- Michelle S. Hirsch,
- Mark Pomerantz,
- Elizabeth Henske,
- Alexander Gusev,
- Kate Lawrenson,
- Toni K. Choueiri,
- David J. Kwiatkowski,
- Matthew L. Freedman
Affiliations
- Amin H. Nassar
- Department of Hematology/Oncology, Yale New Haven Hospital
- Sarah Abou Alaiwi
- Department of Medicine, Brigham and Women’s Hospital
- Sylvan C. Baca
- Department of Medicine, Brigham and Women’s Hospital
- Elio Adib
- Department of Medicine, Brigham and Women’s Hospital
- Rosario I. Corona
- Women’s Cancer Research Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Ji-Heui Seo
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Marcos A. S. Fonseca
- Women’s Cancer Research Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Sandor Spisak
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Talal El Zarif
- Department of Medicine, Brigham and Women’s Hospital
- Viktoria Tisza
- Department of Medical Oncology, Dana-Farber Cancer Institute
- David A. Braun
- Department of Hematology/Oncology, Yale New Haven Hospital
- Heng Du
- Department of Medicine, Brigham and Women’s Hospital
- Monica He
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Abdallah Flaifel
- Department of Pathology, Brigham and Women’s Hospital
- Michel Alchoueiry
- Department of Medicine, Brigham and Women’s Hospital
- Thomas Denize
- Department of Pathology, Brigham and Women’s Hospital
- Sayed G. Matar
- Department of Pathology, Brigham and Women’s Hospital
- Andres Acosta
- Department of Pathology, Brigham and Women’s Hospital
- Sachet Shukla
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Yue Hou
- Department of Medical Oncology, Dana-Farber Cancer Institute
- John Steinharter
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Gabrielle Bouchard
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Jacob E. Berchuck
- Department of Medicine, Brigham and Women’s Hospital
- Edward O’Connor
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Connor Bell
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Pier Vitale Nuzzo
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Gwo-Shu Mary Lee
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Sabina Signoretti
- Department of Pathology, Brigham and Women’s Hospital
- Michelle S. Hirsch
- Department of Pathology, Brigham and Women’s Hospital
- Mark Pomerantz
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Elizabeth Henske
- Department of Medicine, Brigham and Women’s Hospital
- Alexander Gusev
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Kate Lawrenson
- Women’s Cancer Research Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Toni K. Choueiri
- Department of Medicine, Brigham and Women’s Hospital
- David J. Kwiatkowski
- Department of Medicine, Brigham and Women’s Hospital
- Matthew L. Freedman
- Department of Medical Oncology, Dana-Farber Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-023-35833-5
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
The epigenomic landscape of renal cell carcinoma (RCC) remains to be explored. Here, integrative epigenomic analysis of primary human RCC samples and RCC GWAS risk SNPs identifies transcription-factor specific subtypes and enrichment of risk variants in allelically-imbalanced peaks.
