Synthesis, Crystal Structure and Bioactivities of <i>N</i>-(5-(4-chlorobenzyl)-1,3,5-Triazinan-2-Ylidene)Nitramide

Abstract

The compound N-(5-(4-chlorobenzyl)-1,3,5-triazinan-2-ylidene)nitramide (C10H12ClN5O2, M = 269.70) was synthesized and structurally confirmed by 1H NMR, 13C NMR, HRMS and single-crystal x-ray diffraction. The crystal belongs to the monoclinic system with space group P21/c. The title compound consisted of a benzene ring and a 1,3,5-triazine ring. All carbon atoms in the benzene ring were nearly coplanar with a dihedral (C6−C5−C10 and C7−C8−C9) angle of 1.71°and all non-hydrogen atoms of the 1,3,5-triazine ring were not planar, but exhibited a half-chair conformation. The crystal structure was stabilized by a strong intramolecular hydrogen bonding interaction N(3)−H(3)···O(2) and three intermolecular hydrogen bonding interactions, N(2)−H(2)···O(1), N(2)−H(2)···N(4) and N(3)−H(3)···Cl(1). The preliminary bioassay showed that the title compound showed not only aphicidal activity against Sitobion miscanthi (inhibition rate: 74.1%) and Schizaphis graminum (77.5%), but also antifungal activities against Pythium aphanidermatum (62.0%). These results provide valuable guidelines for the design and synthesis of novel aphid control agents and fungicides.

Keywords

• synthesis
• crystal structure
• nitramide
• aphicidal activity
• antifungal activity