Frequency, associated factors, and outcome of raised intraocular pressure in live-related renal transplant recipients: a single-centre experience

Abstract

Objective: To investigate the frequency, associated factors and outcomes of elevated intraocular pressure in live-related renal transplant recipients. Method: The study was conducted at the Department of Ophthalmology, Sindh Institute of Urology and Transplantation, Karachi, in 2023. The data was divided into group A cases having intraocular pressure >23mmHg and group B controls having intraocular pressure 23mmHg. Intergroup comparison between group A and group B showed no significant relationship of intraocular pressure increase with cyclosporine, tacrolimus and everolimus (p>0.05). Azathioprine demonstrated significant association with intraocular pressure elevation at the time of measuring intraocular pressure (p0.05). Patients who had received Antithymocyte globulin (ATG) were found to have remarkable association with raised IOP. No significant link was noted between hypertension, dialysis duration and human leukocyte antigen match (p>0.05). The multivariate analysis showed that Azathioprine was the only factor associated with raised IOP at the time of assessment (p<0.001) Conclusion: There was a potential risk of medication side effects, including secondary glaucoma, among renal transplant recipients. Key Words: Renal transplant, Steroids, Intraocular pressure, Glaucoma.

Keywords

• Renal transplant
• Steroids
• Intraocular pressure
• Glaucoma