Complete Remission of Anaplastic Thyroid Carcinoma after Concomitant Treatment with Docetaxel and Radiotherapy

Ichiro Abe; Satoko Karasaki; Yayoi Matsuda; Shohei Sakamoto; Torahiko Nakashima; Hidetaka Yamamoto; Hisaya Kawate; Keizo Ohnaka; Hisashi Nakashima; Kunihisa Kobayashi; Yoshinao Oda; Masatoshi Nomura; Ryoichi Takayanagi

doi:10.1155/2015/726085

Case Reports in Endocrinology (Jan 2015)

Complete Remission of Anaplastic Thyroid Carcinoma after Concomitant Treatment with Docetaxel and Radiotherapy

Ichiro Abe,
Satoko Karasaki,
Yayoi Matsuda,
Shohei Sakamoto,
Torahiko Nakashima,
Hidetaka Yamamoto,
Hisaya Kawate,
Keizo Ohnaka,
Hisashi Nakashima,
Kunihisa Kobayashi,
Yoshinao Oda,
Masatoshi Nomura,
Ryoichi Takayanagi

Affiliations

Ichiro Abe: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan
Satoko Karasaki: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan
Yayoi Matsuda: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan
Shohei Sakamoto: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan
Torahiko Nakashima: Department of Otorhinolaryngology, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan
Hidetaka Yamamoto: Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan
Hisaya Kawate: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan
Keizo Ohnaka: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan
Hisashi Nakashima: Department of Internal Medicine, Haradoi Hospital, Aoba 6-40-8, Higashi Ward, Fukuoka 813-8588, Japan
Kunihisa Kobayashi: Department of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, 1-1-1 Zokumyoin, Chikushino, Fukuoka 818-8502, Japan
Yoshinao Oda: Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan
Masatoshi Nomura: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan
Ryoichi Takayanagi: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan

DOI: https://doi.org/10.1155/2015/726085
Journal volume & issue: Vol. 2015

Abstract

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Anaplastic thyroid carcinoma (ATC) although rare is the most lethal form of thyroid cancer. The mortality rate for ATC is very high, with a median survival time of only 5 months; the survival rate at 1 year after diagnosis is <20%. Management of ATC is extremely difficult and rife with uncertainties. Herein, we describe a 75-year-old woman who presented with ATC and was successfully treated using concomitant treatment with docetaxel and high-dose radiotherapy. This case appears to be the first to have been reported in the literature involving complete remission of ATC confirmed by autopsy, suggesting the therapeutic potential of this combination.

Published in Case Reports in Endocrinology

ISSN: 2090-6501 (Print); 2090-651X (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://onlinelibrary.wiley.com/journal/7520

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