Transplant International (Sep 2023)
Liver Transplantation for Primary Sclerosing Cholangitis (PSC) With or Without Inflammatory Bowel Disease (IBD)—A European Society of Organ Transplantation (ESOT) Consensus Statement
- M. Carbone,
- M. Carbone,
- A. Della Penna,
- C. Mazzarelli,
- E. De Martin,
- C. Villard,
- C. Villard,
- A. Bergquist,
- P. D. Line,
- P. D. Line,
- P. D. Line,
- J. M. Neuberger,
- S. Al-Shakhshir,
- P. J. Trivedi,
- U. Baumann,
- L. Cristoferi,
- L. Cristoferi,
- J. Hov,
- J. Hov,
- J. Hov,
- B. Fischler,
- B. Fischler,
- N. H. Hadzic,
- D. Debray,
- L. D’Antiga,
- N. Selzner,
- L. S. Belli,
- S. Nadalin
Affiliations
- M. Carbone
- Centre for Autoimmune Liver Diseases, Department of Medicina and Surgery, University of Milano-Bicocca, Milan, Italy
- M. Carbone
- European Reference Network on Hepatological Diseases (ERN RARE-LIVER), IRCCS San Gerardo dei Tintori, Monza, Italy
- A. Della Penna
- Department of General, Visceral and Transplant Surgery, University Hospital Tübingen, Tübingen, Germany
- C. Mazzarelli
- Hepatology and Gastroenterology Unit, ASST GOM Niguarda, Milan, Italy
- E. De Martin
- AP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, Inserm Unité 1193, Université Paris-Saclay, FHU Hépatinov, Centre de Référence Maladies Inflammatoires des Voies Biliaires et Hépatites Auto-Immunes, Villejuif, France
- C. Villard
- European Reference Network on Hepatological Diseases (ERN RARE-LIVER), IRCCS San Gerardo dei Tintori, Monza, Italy
- C. Villard
- Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
- A. Bergquist
- Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
- P. D. Line
- Norwegian PSC Research Center and Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway
- P. D. Line
- Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway
- P. D. Line
- Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
- J. M. Neuberger
- 0Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom
- S. Al-Shakhshir
- 1National Institute for Health and Care Research (NIHR) Birmingham Liver Biomedical Research Centre, Centre for Liver and Gastrointestinal Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
- P. J. Trivedi
- 1National Institute for Health and Care Research (NIHR) Birmingham Liver Biomedical Research Centre, Centre for Liver and Gastrointestinal Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
- U. Baumann
- 2Division of Pediatric Gastroenterology, Hepatology and Liver Transplantation, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
- L. Cristoferi
- Centre for Autoimmune Liver Diseases, Department of Medicina and Surgery, University of Milano-Bicocca, Milan, Italy
- L. Cristoferi
- European Reference Network on Hepatological Diseases (ERN RARE-LIVER), IRCCS San Gerardo dei Tintori, Monza, Italy
- J. Hov
- Norwegian PSC Research Center and Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway
- J. Hov
- Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway
- J. Hov
- Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
- B. Fischler
- 3Department of Pediatrics, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
- B. Fischler
- 4Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
- N. H. Hadzic
- 5Paediatric Centre for Hepatology, Gastroenterology and Nutrition, King’s College, London, United Kingdom
- D. Debray
- 6Unité d’Hépatologie Pédiatrique, Hôpital Necker-Enfants Malades, Centre de Référence Maladies Inflammatoires des Voies Biliaires et Hépatites Auto-Immunes, Filfoie, Paris, France
- L. D’Antiga
- 7Paediatric Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII, Bergamo, Italy
- N. Selzner
- 8Multiorgan Transplant Program, University of Toronto, Toronto, ON, Canada
- L. S. Belli
- Hepatology and Gastroenterology Unit, ASST GOM Niguarda, Milan, Italy
- S. Nadalin
- Department of General, Visceral and Transplant Surgery, University Hospital Tübingen, Tübingen, Germany
- DOI
- https://doi.org/10.3389/ti.2023.11729
- Journal volume & issue
-
Vol. 36
Abstract
Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD) and a lead indication for liver transplantation (LT) in the western world. In this article, we present a Consensus Statement on LT practice, developed by a dedicated Guidelines’ Taskforce of the European Society of Organ Transplantation (ESOT). The overarching goal is to provide practical guidance on commonly debated topics, including indications and timing of LT, management of bile duct stenosis in patients on the transplant waiting list, technical aspects of transplantation, immunosuppressive strategies post-transplant, timing and extension of intestinal resection and futility criteria for re-transplantation.
Keywords
