Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors
Melinda-Ildiko Mitranovici,
Diana Maria Chiorean,
Maria Cezara Mureșan,
Corneliu-Florin Buicu,
Raluca Moraru,
Liviu Moraru,
Titiana Cornelia Cotoi,
Ovidiu Simion Cotoi,
Havva Serap Toru,
Adrian Apostol,
Sabin Gligore Turdean,
Claudiu Mărginean,
Ion Petre,
Ioan Emilian Oală,
Zsuzsanna Simon-Szabo,
Viviana Ivan,
Lucian Pușcașiu
Affiliations
Melinda-Ildiko Mitranovici
Department of Obstetrics and Gynecology, Emergency County Hospital Hunedoara, 14 Victoriei Street, 331057 Hunedoara, Romania
Diana Maria Chiorean
Department of Pathology, County Clinical Hospital of Targu Mures, 540072 Targu Mures, Romania
Maria Cezara Mureșan
Department of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania
Corneliu-Florin Buicu
Public Health and Management Department, “George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania
Raluca Moraru
Faculty of Medicine, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania
Liviu Moraru
Department of Anatomy, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania
Titiana Cornelia Cotoi
Department of Pharmaceutical Technology, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania
Ovidiu Simion Cotoi
Department of Pathology, County Clinical Hospital of Targu Mures, 540072 Targu Mures, Romania
Havva Serap Toru
Department of Pathology, Akdeniz University School of Medicine, Antalya Pınarbaşı, Konyaaltı, 07070 Antalya, Turkey
Adrian Apostol
Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania
Sabin Gligore Turdean
Department of Pathology, County Clinical Hospital of Targu Mures, 540072 Targu Mures, Romania
Claudiu Mărginean
Department of Obstetrics and Gynecology, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania
Ion Petre
Department of Medical Informatics and Biostatistics, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania
Ioan Emilian Oală
Department of Obstetrics and Gynecology, Emergency County Hospital Hunedoara, 14 Victoriei Street, 331057 Hunedoara, Romania
Zsuzsanna Simon-Szabo
Department of Pathophysiology, “George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gheorghe Marinescu Street, 540142 Targu Mures, Romania
Viviana Ivan
Department of Obstetrics and Gynecology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania
Lucian Pușcașiu
Department of Obstetrics and Gynecology, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania
Dysgerminoma represents a rare malignant tumor composed of germ cells, originally from the embryonic gonads. Regarding its incidence, we do not have precise data due to its rarity. Dysgerminoma occurs at a fertile age. The preferred treatment is the surgical removal of the tumor succeeded by the preservation of fertility. Even if a multidisciplinary team, founded in 2009 by a gynecologist, an oncologist, a pediatric oncologist and a pediatric surgeon, under the guidance of the Malignant Germ Cell International Consortium (MaGIC), studies this type of tumor, issues still remain related to the lack of a randomized study and to both the management and understanding of the concept of OMGCTs (ovarian malignant germ cell tumors). The aim of this review is to present from the literature the various approaches for this type of tumor, and, regarding innovative therapies or possible prevention, which can be applied in clinical practice. Multidisciplinarity and treatment in reference centers have proven their usefulness as well.
