Frontiers in Neuroscience (Jul 2022)
Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior
- Feng Zhao,
- Feng Zhao,
- Feng Zhao,
- Feng Zhao,
- Hao Zhang,
- Hao Zhang,
- Hao Zhang,
- Hao Zhang,
- Peng Wang,
- Wenjie Cui,
- Kaiyong Xu,
- Kaiyong Xu,
- Dan Chen,
- Dan Chen,
- Minghui Hu,
- Minghui Hu,
- Minghui Hu,
- Zifa Li,
- Zifa Li,
- Zifa Li,
- Zifa Li,
- Xiwen Geng,
- Xiwen Geng,
- Xiwen Geng,
- Xiwen Geng,
- Sheng Wei,
- Sheng Wei,
- Sheng Wei,
- Sheng Wei
Affiliations
- Feng Zhao
- Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China
- Feng Zhao
- Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China
- Feng Zhao
- TAIYUE Postdoctoral Innovation and Practice Base, Jinan, China
- Feng Zhao
- Chinese Medicine and Brain Science Core Facility, Shandong University of Traditional Chinese Medicine, Jinan, China
- Hao Zhang
- Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China
- Hao Zhang
- Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China
- Hao Zhang
- TAIYUE Postdoctoral Innovation and Practice Base, Jinan, China
- Hao Zhang
- Chinese Medicine and Brain Science Core Facility, Shandong University of Traditional Chinese Medicine, Jinan, China
- Peng Wang
- School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China
- Wenjie Cui
- Department of Biology, Southern University of Science and Technology, Shenzhen, China
- Kaiyong Xu
- Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China
- Kaiyong Xu
- Chinese Medicine and Brain Science Core Facility, Shandong University of Traditional Chinese Medicine, Jinan, China
- Dan Chen
- Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China
- Dan Chen
- Chinese Medicine and Brain Science Core Facility, Shandong University of Traditional Chinese Medicine, Jinan, China
- Minghui Hu
- Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China
- Minghui Hu
- TAIYUE Postdoctoral Innovation and Practice Base, Jinan, China
- Minghui Hu
- Chinese Medicine and Brain Science Core Facility, Shandong University of Traditional Chinese Medicine, Jinan, China
- Zifa Li
- Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China
- Zifa Li
- Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China
- Zifa Li
- TAIYUE Postdoctoral Innovation and Practice Base, Jinan, China
- Zifa Li
- Chinese Medicine and Brain Science Core Facility, Shandong University of Traditional Chinese Medicine, Jinan, China
- Xiwen Geng
- Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China
- Xiwen Geng
- Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China
- Xiwen Geng
- TAIYUE Postdoctoral Innovation and Practice Base, Jinan, China
- Xiwen Geng
- Chinese Medicine and Brain Science Core Facility, Shandong University of Traditional Chinese Medicine, Jinan, China
- Sheng Wei
- Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China
- Sheng Wei
- Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China
- Sheng Wei
- TAIYUE Postdoctoral Innovation and Practice Base, Jinan, China
- Sheng Wei
- Chinese Medicine and Brain Science Core Facility, Shandong University of Traditional Chinese Medicine, Jinan, China
- DOI
- https://doi.org/10.3389/fnins.2022.919890
- Journal volume & issue
-
Vol. 16
Abstract
Autism spectrum disorders (ASD) is a group of generalized neurodevelopmental disorders. Its main clinical features are social communication disorder and repetitive stereotyped behavioral interest. The abnormal structure and function of brain network is the basis of social dysfunction and stereotyped performance in patients with autism spectrum disorder. The number of patients diagnosed with ASD has increased year by year, but there is a lack of effective intervention and treatment. Oxytocin has been revealed to effectively improve social cognitive function and significantly improve the social information processing ability, empathy ability and social communication ability of ASD patients. The change of serotonin level also been reported affecting the development of brain and causes ASD-like behavioral abnormalities, such as anxiety, depression like behavior, stereotyped behavior. Present review will focus on the research progress of serotonin and oxytocin in the pathogenesis, brain circuit changes and treatment of autism. Revealing the regulatory effect and neural mechanism of serotonin and oxytocin on patients with ASD is not only conducive to a deeper comprehension of the pathogenesis of ASD, but also has vital clinical significance.
Keywords
